Publications by authors named "Chisato Tsuboi"

Article Synopsis
  • There is a debate regarding liver transplant eligibility for patients with alcoholic liver disease (ALD) since it's considered self-inflicted, and this study examines the psychosocial traits of ALD liver transplant recipients (ALD-R) versus non-alcoholic liver disease (NALD) recipients (NALD-R).
  • The study involved 75 patients over eight years, comparing their psychosocial characteristics before and after liver transplantation using various assessment tools, revealing that ALD-RC and NALD-RC had similar traits pre-surgery, with a few exceptions.
  • After transplantation, the only notable difference in psychosocial characteristics was observed in social support scores at the three-month mark, suggesting similarities in psychosocial aspects for ALD-RC
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BACKGROUND Around 20-30% of patients who undergo liver transplantation (LT) for alcoholic liver disease (ALD) will resume heavy drinking after LT. It is crucial to control post-transplant relapse of alcohol use, because alcoholic recidivism has been shown to have a negative impact on post-transplant compliance and long-term outcomes of LT recipients. However, there is currently no specific, effective psychiatric intervention for preventing additional alcohol consumption in clinical practice.

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Aim: To investigate factors, including psychosocial factors, associated with alcoholic use relapse after liver transplantation (LT) for alcoholic liver disease (ALD).

Methods: The clinical records of 102 patients with ALD who were referred to Nagoya University Hospital for LT between May 2003 and March 2015 were retrospectively evaluated. History of alcohol intake was obtained from their clinical records and scored according to the High-Risk Alcoholism Relapse scale, which includes duration of heavy drinking, types and amount of alcohol usually consumed, and previous inpatient treatment history for alcoholism.

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Patients with alcohol-related liver failure are highly probably complicated by alcohol dependence according to the definition in WHO-ICD. Not a few such patients are introduced to liver transplant program when they are decompensated and face the need for liver replacement. Transplant team should evaluate them thoroughly also from the viewpoint of dependence medicine and multidisciplinary approach including psychiatrist is indispensable for the decision of psychosocial indication.

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Objectives: Consensus regarding psychosocial aspects relevant for the liver transplantation indication criteria in case of alcohol-related liver failure remains to be established. Thus we investigated the psychosocial aspects of candidates for liver transplantation for alcohol-related liver failure in order to determine the indication criteria.

Subjects: We evaluated the psychosocial aspects of 19 candidates (14 male and 5 female patients) who met the physical liver transplantation indication criteria for alcohol-related liver failure at Nagoya University Hospital between 2004 and 2012.

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