Publications by authors named "Chisato Kodera"
We report a case of a pregnant woman with a history of ascending arch replacement for aortic dissection who still had a residual descending aortic dissection. She underwent urgent genetic testing to identify hereditary aortic-related diseases that might be useful in perinatal management. A mutation in the myosin heavy chain gene (MYH11), indicating a high risk of aortic dissection but a low impact on other vascular systems and organs, was identified.
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- The Japan Society of Obstetrics and Gynecology organized "Welcome to OBGYN World!" (WOW!) to address a decline in doctors specializing in obstetrics and gynecology, particularly targeting lower-grade medical students.
- The event was held online to ensure safety during the COVID-19 pandemic and involved participation from 60 of 82 medical schools in Japan, with 285 students and 106 tutors engaged.
- Post-event feedback revealed that a significant majority of participants (97.6%) developed a strong interest in the specialty, while all tutors acknowledged the event's effectiveness in recruitment, leading to plans for an annual WOW! event.
Article Synopsis
- The study focuses on how gene expression and chromatin changes occur during spermatogenesis, especially during meiotic prophase.
- Researchers discovered a protein complex made up of ZFP541 and KCTD19 that is crucial for regulating transcription during this phase in male mice.
- ZFP541 is shown to bind to and suppress various genes linked to transcription and chromatin modifications, which helps in ensuring the proper progression and completion of meiotic prophase.
A 33-year-old primiparous woman with progressive idiopathic juvenile osteoporosis (IJO) who had had multiple vertebral compressions and bilateral femoral neck fractures since the age of 15 years presented for perinatal management at 11 weeks of gestation. Her vertebral bone mass was 0.634 g/cm before pregnancy.
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- - Meiosis is a complex cell division process, and researchers identified the gene Kctd19 as crucial for this process in male mice using CRISPR/Cas9 to screen genes involved in reproduction.
- - Kctd19 deficiency didn't hinder early meiosis stages like synapsis but did cause spermatocytes to undergo apoptosis during the transition from metaphase to anaphase.
- - The study also found that KCTD19 interacts with proteins ZFP541 and HDAC1, with both KCTD19 and ZFP541 being essential for normal meiosis, specifically in preventing DNA damage in spermatocytes.
Article Synopsis
- - The study explores the differing perceptions of self-training and overtime work among doctors of varying experience levels in response to new regulations in Japan aimed at reducing overtime.
- - A survey conducted among 1,256 members of the Japan Society of Obstetrics and Gynecology found that younger doctors (≤5 years) believe these regulations may improve service quality, while experienced doctors (≥20 years) fear quality may decline.
- - The findings highlight a significant generational divide in attitudes towards work regulations, suggesting that more experienced doctors are concerned about the impact on medical training and service quality due to reduced working hours.
Aim: This study aimed to evaluate the clinical features and pregnancy outcomes of placental mesenchymal dysplasia (PMD) in Japan.
Methods: We requested detailed clinical information and placental tissue of PMD cases in 2000-2018 from Japanese facilities with departments of obstetrics and gynecology and analyzed the pregnancy course and neonatal outcomes.
Results: We collected 49 cases of PMD.
Sac-Type Congenital Diaphragmatic Hernia: A Case Report of Two Siblings.
Case Rep Obstet Gynecol
August 2018
Congenital diaphragmatic hernia (CDH), a herniation of the abdominal contents through a defect or hypoplasia of the diaphragm, is a relatively common, severe congenital anomaly. Here we present the first case of two siblings with possibly isolated sac-type CDH and with a suspected genetic etiology. Although sibling recurrence of isolated CDH is rare, the incidence is higher than in the general population.
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