Publications by authors named "Chisato Emura"
Article Synopsis
- Small interfering RNA (siRNA) and short hairpin RNA (shRNA) are commonly used tools for RNA interference (RNAi), but new forms like enforced strand bias (ESB) RNA have been developed to improve efficacy.
- ESB RNA features a unique chemical structure that allows it to work without the need for Dicer, surpassing some limitations of traditional siRNA.
- This novel RNAi reagent shows promise by effectively silencing target sequences that traditional siRNA cannot, making it a potentially valuable addition to RNAi technology.
Six new ceramide dihexosides, amphimelibiosides A-F (1-6), were isolated from a Japanese marine sponge Amphimedon sp. The structure of amphimelibioside C (3), which is a major component of amphimelibiosides, was determined by 2D NMR techniques, chemical degradation, and a semisynthetic method to be 1-O-[beta-D-glucopyranosyl-(1-->6)-alpha-D-galactopyranosyl]-(2S,3S,4R,6E)-2-[(2'R)-2-hydroxydocosanoyl]-2-amino-6-octadecene-1,3,4-triol. The structures of the other constituents were elucidated by a combination of mass spectra, (1)H NMR, and GC-MS analysis.
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