Publications by authors named "Chisaki Ito"
Article Synopsis
- Differentiation therapy with all-trans retinoic acid (ATRA) is effective for acute promyelocytic leukemia (APL), but there are limitations in its tolerance and application that prompted researchers to seek new inducers of myeloid differentiation.
- The study identified the kinase inhibitors PD169316, SB203580, SB202190, and triciribine (TCN) as potent enhancers of CD11b expression in APL cells, with a focus on TCN due to its good tolerance in patients.
- TCN promotes the differentiation of APL and acute myeloid leukemia (AML) cells by activating the ERK pathway and enhancing pathways associated with hematopoietic lineage and cytokine interactions, revealing
Kidney Int Rep
March 2024
Article Synopsis
- Glomerulonephritis is common in ANCA-associated vasculitis and significantly impacts patient outcomes; this study focuses on Japanese patients to develop a new prognostic score for kidney health.
- The research involved 221 patients undergoing kidney biopsies, analyzing various kidney lesions, and validating existing scoring systems for predicting kidney disease progression.
- A new scoring system called the Percentage of ANCA Crescentic Score (PACS) was created, which effectively predicts the risk of end-stage kidney disease and demonstrates comparable results to established scores.
