Publications by authors named "Chirouze Catherine"
Article Synopsis
- The study aimed to assess how general practitioners (GPs) and pediatricians diagnose and manage facial nerve palsy in children suspected of having Lyme neuroborreliosis (LNB).
- A national survey conducted from September 2018 to January 2020 yielded 598 responses, revealing that many practitioners felt uncomfortable with diagnosing LNB and often required specialist consultations or hospital admissions.
- Antibiotic treatment varied slightly between age groups, with amoxicillin and ceftriaxone being the most common choices, but overall, there was little difference in management practices between GPs and pediatricians.
In this multicenter study conducted in France, we challenged the hypothesis of the transmission of pathogens other than spp. in 22 patients developing erythema migrans following a tick bite. Using a combination of high-throughput microfluidic PCRs and agnostic metagenomics on skin biopsies and blood samples, no microorganisms other than spp.
View Article and Find Full Text PDFLinezolid in enterococcal urinary tract infection: a multicentre study.
Eur J Clin Microbiol Infect Dis
November 2024
Purpose: Few data have been published on the efficacy of linezolid in enterococcal urinary tract infection (e-UTI). The aims of this study were to describe the characteristics of patients with enterococci UTI treated with linezolid, and to evaluate the efficacy and the tolerance of linezolid treatment.
Methods: An observational multicentre retrospective study was conducted in 5 hospitals in France.
Article Synopsis
- A study examined patients with unexplained neurological symptoms and suspected Lyme neuroborreliosis (LNB) by comparing characteristics of those with and without LNB.
- Out of 155 patients, 29% were diagnosed with LNB, with key findings indicating certain neurological symptoms like facial nerve palsy and shorter duration of symptoms linked to LNB.
- Many patients, regardless of LNB diagnosis, reported similar non-neurological symptoms, suggesting that over a quarter of those seeking care had conditions unrelated to LNB.
Introduction: In case of pneumonia, some biological findings are suggestive for Legionnaire's disease (LD) including C-reactive protein (CRP). A low level of CRP is predictive for negative Legionella Urinary-Antigen-Test (L-UAT).
Method: Observational retrospective study in Nord-Franche-Comté Hospital with external validation in Besançon University Hospital, France which included all adults with L-UAT performed during January 2018 to December 2022.
Compared Performance of the 2023 Duke-International Society for Cardiovascular Infectious Diseases, 2000 Modified Duke, and 2015 European Society of Cardiology Criteria for the Diagnosis of Infective Endocarditis in a French Multicenter Prospective Cohort.
Clin Infect Dis
April 2024
Article Synopsis
- The 2023 Duke-ISCVID criteria for diagnosing infective endocarditis (IE) were tested against the previous 2000 Modified Duke and 2015 ESC criteria using a large patient cohort treated for the condition.
- A total of 1194 patients were analyzed, revealing that the 2023 criteria had the highest sensitivity (97.6%) but the lowest specificity (46.0%) compared to the other criteria.
- The lower specificity in the 2023 criteria was largely due to the inclusion of patients with cardiac implanted electronic devices (CIED), highlighting the need for cautious interpretation in this group.
Persistent headaches one year after bacterial meningitis: prevalence, determinants and impact on quality of life.
Eur J Clin Microbiol Infect Dis
December 2023
Article Synopsis
- After people have bacterial meningitis, some experience headaches that last a long time, and these can affect their daily life.
- In a study with 277 patients, many reported headaches before, when they got sick, and one year later; factors like being female and having headaches before meningitis made them more likely to still have headaches later.
- The headaches were linked to feeling more disabled, having physical and mental health issues, and a lower quality of life one year after the illness.
The effects of switching from ceftriaxone to cefotaxime on the occurrence of third-generation cephalosporin-resistant Enterobacterales: A stepped-wedge cluster randomized trial.
Infect Dis Now
February 2024
Article Synopsis
- The study aimed to assess how switching from ceftriaxone to cefotaxime affects the rates of third-generation cephalosporin-resistant Enterobacterales (3GC-RE).
- Conducted over 24 months, the trial compared a control phase (where both antibiotics were used) to an intervention phase (where only cefotaxime was prescribed).
- Results showed a decrease in 3GC-RE incidence during the intervention phase, suggesting that cefotaxime may be more effective in reducing these resistant infections, although further research is necessary to validate these findings.
Article Synopsis
- * Out of 663 patients, 48 (7.24%) developed FUSAUTI, with a notable number experiencing severe complications like sepsis. Common bacteria involved included E. coli and Enterococcus.
- * Key risk factors for developing FUSAUTI included being female, having multiple health issues, undergoing urethral stent placement alongside ureteral stent insertion, and a recent history of urinary infections; only urethral stent placement was identified as a modifiable risk factor.
Positive intrathecal anti-Borrelia antibody synthesis: what are the implications for clinical practice? Clinical features and outcomes of 138 patients in a French multicenter cohort study.
Eur J Clin Microbiol Infect Dis
April 2023
Article Synopsis
- The study investigated the characteristics, management, and residual symptoms in patients diagnosed with Lyme neuroborreliosis (LNB) over a decade in France, focusing on both definite and possible cases.
- Out of 138 adult patients, those with definite LNB showed shorter symptom duration and higher rates of radicular pain compared to those with possible LNB.
- At follow-up, 59.7% of patients reported residual symptoms, with early diagnosis and treatment identified as critical for better outcomes and reducing long-term effects.
Introduction: Data on infections associated with cerebrospinal fluid shunt (CSF-S) or device-associated infection (CSF-SDI) are limited in adults. We performed a retrospective study to describe characteristics, management, and outcome of CSF-SDI.
Methods: All patients with CSF-SDI and admitted to our institution from January 2013 to December 2019 were included.
Article Synopsis
- A study was conducted to assess the prevalence and factors related to nasal carriage of the bacterium CC398 in healthy blood donors and hospitalized patients at a French university hospital.
- Results showed that the prevalence of CC398 was higher among healthy blood donors (7.3%) compared to hospitalized patients (3.8%), with a notable absence of MRSA strains.
- Factors like prior antibiotic use and active smoking increased the likelihood of nasal carriage in healthy individuals, while older age and a history of neurological disease were associated with carriage in hospitalized patients; overall, no environmental sources were identified as risk factors.
Article Synopsis
- The study investigated the prevalence and characteristics of sleep apnea (SA) in patients who were hospitalized in the ICU for severe COVID-19, focusing on their apnea hypopnea index (AHI) three months post-illness.
- Out of 68 patients, a staggering 91% developed SA, with 44 individuals experiencing moderate to severe cases, while 62% of patients had other health issues, like obesity and hypertension.
- The findings emphasize the need for sleep assessments after ICU care for COVID-19, as those with moderate to severe SA had more severe COVID-19 symptoms and longer hospital stays.
Objectives: Lethality of (Sa) infective endocarditis (IE) is high and might be due to yet unidentified prognostic factors. The aim of this study was to search for new potential prognostic factors and assess their prognostic value in SaIE.
Materials And Methods: We used a two-step exploratory approach.
Prevalence of post-acute coronavirus disease 2019 symptoms twelve months after hospitalization in participants retained in follow-up: analyses stratified by gender from a large prospective cohort.
Clin Microbiol Infect
February 2023
Article Synopsis
- A study examined the long-term symptoms of COVID-19 in patients 12 months after hospitalization, finding that 27% experienced three or more persistent symptoms, mainly fatigue, dyspnoea, and joint pain.
- The research included 737 participants, with a notable difference in outcomes based on gender; women reported more persistent symptoms, anxiety, and depression compared to men.
- Despite recovery progress, many who were employed before hospitalization still faced challenges, as 27% remained on sick leave at the 12-month mark, highlighting the ongoing impact of COVID-19 on quality of life.
Long-term evolution data of olfactory disorders (OD) in COVID-19 are limited. ANOSVID is a retrospective study in Nord Franche-Comté Hospital (France) that included COVID-19 patients from the first wave. The aim was to describe OD evolution, especially in patients with persistent OD (p-OD group) in comparison with patients with resolved OD (r-OD group).
View Article and Find Full Text PDFTo describe the number of prosthetic joint infections (PJIs) with late documentation and to identify associated factors. Bacterial PJIs with surgical management between November 2015 and November 2019 in a French center were analyzed. Results of short (72 h) and late culture (at 14 days) were analyzed.
View Article and Find Full Text PDFOlfactory disorders (OD) pathogenesis, underlying conditions, and prognostic in coronavirus disease 2019 (COVID-19) remain partially described. ANOSVID is a retrospective study in Nord Franche-Comté Hospital (France) that included COVID-19 patients from March 1 2020 to May 31 2020. The aim was to compare COVID-19 patients with OD (OD group) and patients without OD (no-OD group).
View Article and Find Full Text PDFObjectives: Nocardiosis is a rare opportunistic infection that is frequently associated with dissemination (i.e. involvement of several body sites).
View Article and Find Full Text PDFArticle Synopsis
- Lymphopenia, a condition where lymphocyte (a type of white blood cell) levels are low, is often found in sepsis patients and is linked to higher mortality rates.
- The study examined if lymphopenia could be a reliable indicator of outcomes in patients with bacteremia, involving 574 individuals from two hospitals.
- Results showed that initial lymphocyte counts and changes over the first four days did not predict 12-week mortality, suggesting the need for a better understanding of each patient’s immune profile before pursuing immune therapies.
Introduction: We aimed to describe patients with coexisting infective endocarditis (IE) and bacterial meningitis (BM).
Methods: We merged two large prospective cohorts, an IE cohort and a BM cohort, with only cases of definite IE and community-acquired meningitis. We compared patients who had IE and BM concurrently to patients with IE only and BM only.
Background: Infective endocarditis (IE) typically occurs in patients with underlying cardiac conditions (UCC). Little is known about IE in patients without UCC. We aimed to describe the clinical, microbiological and imaging characteristics, management, and in-hospital mortality of IE patients without UCC.
View Article and Find Full Text PDFAims: To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry.
Methods And Results: Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n = 698, 28.