[Intravenous thrombolytic therapy of ischemic stroke with the drug Revelisa in real clinical practice: results of the IVT-AIS-R study].

Objective: Evaluation of the safety and effectiveness of thrombolytic therapy (TLT) with the drug Revelisa (alteplase) in patients with ischemic stroke (AI) in real clinical practice.

Material And Methods: An open prospective multicenter non-interventional register study was conducted, which included 550 patients with AI - 259 (47.1%) women and 291 (52.

Boosted excitation of the fifth cyclotron harmonic based on frequency multiplication in conventional gyrotrons.

We discovered a specific property of the eigenmodes of a cylindrical waveguide, due to which efficient mode excitation at ultrahigh (s=4n+1, n is integer) multiples of the gyrofrequency can be provided by a polyhelical weakly relativistic electron beam, standardly used for gyrotron operation. In the proof-of-principle experiment with a V-band gyrotron driven by a 25-keV, 2-A beam, about 100 mW radiation power at the fifth cyclotron harmonic (0.22 THz) has been detected in the cw regime.

[Nonimmunogenic staphylokinase in the treatment of acute ischemic stroke (FRIDA trial results)].

Aim Of The Study: To investigate the efficacy and safety of non-immunogenic staphylokinase (NS) compared with alteplase (A) in patients with acute ischemic stroke (AIS) within 4.5 h after symptom onset.

Material And Methods: 336 patients with IS within 4.

[Intravenous thrombolytic therapy with Revelisa of ischemic stroke in real-world clinical practice: interim results of an open-label, prospective, multicenter, non-interventional study IVT-AIS-R].

Objective: To assess the safety and efficacy of Revelisa in patients with ischemic stroke in real-world clinical practice.

Material And Methods: The interim analysis of an open-label, prospective, multicenter, non-interventional study IVT-AIS-R included 223 patients (50.2% women and 49.

Oxidized Cell-Free DNA Role in the Antioxidant Defense Mechanisms under Stress.

The present study focuses on the investigation of the oxidized cell-free DNA (cfDNA) properties in several experimental models, including cultured cerebellum cells, peripheral blood lymphocytes (PBL), plasma, and hippocampus under an acute and chronic unpredictable stress model in rats. Firstly, our study shows that Spectrum Green fluorescence-labeled oxidized cfDNA fragments were transferred into the cytoplasm of 80% of the cerebellum culture cells; meanwhile, the nonoxidized cfDNA fragments do not pass into the cells. Oxidized cfDNA stimulates the antioxidant mechanisms and induction of transcription factor NRF2 expression, followed by an activation of NRF2 signaling pathway genes-rise of and gene expression and consequently NRF2 protein synthesis.

[Algorithms of the correction of fluid and electrolyte disorders in patients with severe ischemic stroke].

Aim: To develop a practical algorithm for the correction of sodium levels and osmolality of blood plasma during the acute period of severe ischemic stroke (IS).

Material And Methods: One hundred and fifty patients with cardioembolic or atherothrombotic stroke, aged from 30 to 80 years, hospitalized in the first 12 h after symptom emergence, were examined. Neurological deficit was assessed with the NIHSS.

PROGNOSTIC SIGNIFICANCE OF WATER AND ELECTROLYTE DISORDERS IN THE ACUTE PERIOD OF SEVERE ISCHEMIC STROKE.

The Aim: to study and identify the impact of the osmolarity blood plasma level on outcomes atherothrombotic ischemic stroke, and cardioembolic subtype.

Materials And Methods: The study included 150 patients with severe ischemic stroke pathogenesis of diferent subtypes. We studied the effect of the of the osmolarity bloodplasma level in the first dayfrom the disease beginning to ischemic stroke prognosis.

[Hypovolemic hyponatremia at the onset of severe ischemic stroke as a predictor of adverse outcome].

Aim: To study the prognostic value of disturbances of the water and electrolyte homeostasis in the acute stage of ischemic stroke (II) and their impact on the course and outcome.

Material And Methods: Disturbances of the water and electrolyte homeostasis associated with plasma sodium fluctuations were studied in 150 patients with severe II.

Results: The poor outcome was associated with plasma osmolarity >297 mOsmol/L and plasma sodium concentration >155 mOsmol/L in the first day of severe II and with >303 mOsmol/L and >161 mOsmol/L, respectively, in the 3rd and 5th days.

Experimental tests of a 263 GHz gyrotron for spectroscopic applications and diagnostics of various media.

A 263 GHz continuous-wave (CW) gyrotron was developed at the IAP RAS for future applications as a microwave power source in Dynamic Nuclear Polarization / Nuclear magnetic resonance (DNP/NMR) spectrometers. A new experimental facility with a computerized control was built to test this and subsequent gyrotrons. We obtained the maximum CW power up to 1 kW in the 15 kV/0.

[Effect of fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) on gas exgange in patients after cardiac surgery].

Unlabelled: Fiberoptic bronchoscopy (FOB) has become a commonplace procedure in ICUs in patients after operation. We studied the outcomes of 35 FOBs performed in 26 patients (18 male and 8 female) during their stay in the ICU of "St. Ekaterina" University Hospital in Sofia after cardiac surgery with Cardiopulmonary Bypass.

[Upper gastrointestinal bleeding after cardiac surgery and invasive cardiology procedures--prophylaxis and therapy].

The abdominal complications after cardiac surgery prolong the hospitalization and increase the cost. The operative treatment of these complications is having high mortality rate--up to 85%. In this study we investigated the upper gastrointestinal bleeding: the causes, the diagnostic and therapeutic approaches, and the difficulties of the treatment.

[Initial experience in endovascular treatment of abdominal aortic aneurysms in Bulgaria].

The abdominal aneurysm imposes prominent epidemiological impact due to its high incidence and life threatening complications. The first steps in endovascular treatment of abdominal aneurysms in Bulgaria are herein described. Five bifurcated and one straight stent-grafts were implanted in the ,,St.

[Effect of antegrade brain perfusion on neurogical complications after surgical treatment of aneurysm and dissection with circulatory arrest].

From January 2001 until December 2003 twenty patients have been operated for acute or chronic dissection with involvement of the aortic arch. 16 of them were men, and 4--women, with middle age of 57 years. Two methods of cerebral perfusion have been used--hypothermic circulatory arrest (HCA) or selective antegrade cerebral perfusion (ACP).

[Multiple coronary endarteriectomy in patients with diffusial coronary disease].

Unlabelled: In recent years the profile of patients with CAD is continuously changing, often with previous operation or stenting. Multiple coronary endarterectomies have been utilized as an adjunct to CABG in this select group of patients to achieve complete revascularization because of the diffuse CAD.

Methods: Between January 1997 and December 2001 eighty eight consecutive patients undergoing first time CABG with more than two CE were compared with a control group of 967 patients undergoing CABG without CE.

[Surgical treatment of acquired mitral valve diseases--five-year analysis of early and late results].

Unlabelled: The indications for mitral valve repair or mitral valve replacement are worldwide accepted, but they still depend of the personal experience of the surgeon and the tradition in the respective cardio-vascular clinic. Valve repair had many advantages over the replacement, but the long-term durability and the reoperations remain a major problem. In this retrospective review we examine the five years results of the surgical treatment of mitral valve diseases and the factors influencing the choice of the operation, the mortality and morbidity.

[The first case of one stage endovascular treatment of the stenosis in the celiac trunk, bilateral renal arteries, and right common iliac arteries].

Although not very often diagnosed, the acute and chronic mesenterial ischemia is advancing and life threatening condition. When associated with multivascular pathology compromising the perfusion and causing multiple organ failure the choice of treatment is a challenge. In such cases the radical surgical treatment is associated with high morbidity and mortality.

[Endovascular therapy of acute traumatic vascular peripheral dissections using self-expandable stents].

Percutaneous peripheral and coronary interventions as well as surgical procedures can be complicated by dissections and traumatic lesions of peripheral arteries. Posttraumatic peripheral dissections can be threatening for the extremities and often their management might be a challenge. Open surgery requires wide exposure and dissection of posttraumatic tissues.

[Angioplasty and stenting of extracranial cerebral vessels].

Unlabelled: The stroke is one of the major causes for death and invalidization in the modern society. In about 30% of the cases the stroke is attributed to stenosis of a supraaortic vessel. In the last few years the percutaneous angioplasty and stenting is an alternative method of the classical surgical treatment--the carotid thrombendarterectomy.

[Stenting of the right subclavian artery posttraumatic false aneurysm].

Posttraumatic false aneUrysms can be life threatening and often their management might be a challenge, because of poor general condition as well as because of specific technical difficulties. Open surgery requires wide exposure and dissection of posttraumatic tissues. Endovascular techniques using stent-grafts gains popularity because of high efficiency, safety and good results.

[Surgical treatment of coronary disease with ischemic mitral regurgitation--early and late results].

Unlabelled: Patients with ischemic mitral incompetence have a high operative risk and the advantage of repair over replacement in those patients is unclear. In cases of moderate mitral regurgitation and coronary artery disease operative strategy continues to be debated between coronary artery bypass grafting (CABG) alone and concomitant valve replacement or repair. The objective of the study is to review our experience with the different surgical treatments and to assess the impact of pre- and intraoperative factors on mortality, morbidity and long-term survival.

[Anesthesia and analgesia for lower limb amputation].

This study describes the methods of anesthesia and analgesia used in 296 limb amputations for vascular disease over a fifteen year period (1986-2000). The main type of anesthesia was general in 55%, epidural in 29% and spinal in 14%: there were no significant differences for ASA grade, age, or amputation level, nor any statistical differences in mortality for each method of anesthesia. The main methods of analgesia in the first 48 hours changed between 1986 and 1998, with decreasing intramuscular and oral opioids (from 42% to 1%, and from 14% to 1% respectively) while epidurals became the commonest method (2% in 1986 and 83% in 2000).

[Surgical treatment of vasorenal hypertension in children].

Renal artery hypoplasia is a relatively rare condition in childhood causing renovascular hypertension. We present a case of hypoplasia of the proximal two thirds of the right renal artery, and almost normal distal third of the renal artery as well as normal parenchymal branches managed with hypogastric autoarterial conduit. We discuss conduit options and technical considerations when dealing with this delicate condition in paediatric population.