Background: The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) is a serious pest of maize.
View Article and Find Full Text PDFIn agricultural ecosystems, pest insects, pathogens, and reduced soil fertility pose major challenges to crop productivity and are responsible for significant yield losses worldwide. Management of belowground pests and diseases remains particularly challenging due to the complex nature of the soil and the limited reach of conventional agrochemicals. Boosting the presence of beneficial rhizosphere organisms is a potentially sustainable alternative and may help to optimize crop health and productivity.
View Article and Find Full Text PDFThe currently available treatments for Chagas disease show limited therapeutic potential and are associated with serious side effects. Attempting to find alternative drugs isolated from Nature as agents against Trypanosoma cruzi has been our goal. Recently, we have demonstrated the in vitro anti-T.
View Article and Find Full Text PDFA bioactive-guided investigation of the hydro-ethanolic extract of aerial parts of Aristeguietia glutinosa Lam. resulted in the isolation of two diterpenoids, (+)-15-hydroxy-labd-7-en-17-al (1) and (+)-13,14,15,16-tetranor-labd-7-en-17,12-olide (2), as the anti-Trypanosoma cruzi active principles. The structures of 1 and 2 were determined by spectroscopic analysis.
View Article and Find Full Text PDFPhytochemical investigation of secondary metabolites of the Ecuadorian plant Schistocarpha eupatorioides (Fenzl) Kuntze (Asteraceae) afforded three phytyl fatty acid esters along with a mixture of unidentified polyprenols, the very well known sterols beta-sitosterol and stigmasterol, and their corresponding fatty acid esters and glucosyl derivatives. The structures of the compounds were elucidated on the basis of various spectroscopic means. In addition, a volatile fraction was separated the composition of which, comprising sesquiterpene hydrocarbons as the main fraction, was determined by GC-MS.
View Article and Find Full Text PDFFive new naturally occurring anthracene derivatives, 1,4,10-trimethoxyanthracene-2-carbaldehyde (1), (1,4,10-trimethoxy-2-anthracen-2-yl)methanol (2), 1,4,8,10-tetramethoxyanthracene-2-carbaldehyde (3), 1,4,10-trimethoxyanthracene-2-carboxylic acid (4), and 1,3-dimethoxy-2-methoxymethylanthraquinone (5), were isolated from Coussarea macrophylla along with three known compounds, 3-hydroxy-1-methoxy-2-methoxymethylanthraquinone (6), scopoletin, and 3-epi-pomolic acid. The structures of 1-5 were determined on the basis of analysis of their spectroscopic data and by total synthesis.
View Article and Find Full Text PDFFolk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Extracts prepared from 10 South American medicinal plants (Baccharis trinervis, Baccharis teindalensis, Eupatorium articulatum, Eupatorium glutinosum, Tagetes pusilla, Neurolaena lobata, Conyza floribunda, Phytolacca bogotensis, Phytolacca rivinoides and Heisteria acuminata) were screened for in vitro antiviral activity against herpes simplex type I (HSV-1), vesicular stomatitis virus (VSV) and poliovirus type 1. The most potent inhibition was observed with an aqueous extract of B.
View Article and Find Full Text PDFEthanolic extracts from 15 plant species, representing eight different families, used in traditional medicine in Ecuador were evaluated for antiinflammatory and antioxidant activities. Conyza floribunda, Eupatorium articulatum, Bonafousia longituba, Bonafousia sananho, Tagetes pusilla and Piper lenticellosum extracts showed a significant antiinflammatory activity in vivo in the carrageenan-induced paw oedema model in mice. The extracts were also tested in vitro for their ability to inhibit lipid peroxidation and to scavenge superoxide and hydroxyl radicals.
View Article and Find Full Text PDF