Publications by authors named "Chiraz Fayech"
Purpose: Childhood cancer survivors (CCS) have an increased risk of developing late chronic diseases, which can be influenced by the cancer type and its treatment. These chronic diseases can be severe and disabling, typically emerging years to decades after treatment. These deficits negatively impact quality of life, intelligence quotient, and memory.
View Article and Find Full Text PDFBackground: Optic pathway gliomas (OPGs) represent 5% of childhood brain tumors. Successive relapses lead to multiple treatments exposing to late complications.
Methods: We included patients treated at Gustave Roussy (GR) between January 1980 and December 2015 for OPG, before 18 years old and alive at 5 years from diagnosis.
Research Question: What are current practices of post-treatment fertility preservation in male childhood cancer survivors (CCS) who have not benefitted from pre-therapeutic fertility preservation in France and other European countries?
Design: A survey was conducted of all fertility preservation centres in France (n = 30) and European fertility specialists (n = 9) in five European countries. Eight clinical cases and 40 questions were included to assess the effect of age at diagnosis, type of treatment (alkylating-agents, orchidectomy, testicular radiotherapy) and sperm parameters on the probability of a post-treatment fertility preservation proposal. Demographic characteristics of the responding practitioner were also collected.
Article Synopsis
- A study examined how well long-term childhood cancer survivors at high risk for cardiomyopathy followed cardiac screening guidelines, involving nearly 1,000 patients.
- Only 32% of participants had an echocardiogram in the last five years, with lower adherence among males, older survivors, and those with specific cancer types like Neuroblastoma and CNS tumors.
- Attending long-term follow-up visits significantly increased the likelihood of completing echocardiograms, highlighting the need for better strategies to encourage more survivors to participate in recommended cardiac surveillance.
Background: Long-term follow-up (LTFU) clinics have been developed but only some childhood cancer survivors (CCS) attend long-term follow-up (LTFU).
Objective: To identify factors that influence LTFU attendance.
Methods: Five-year CCS treated for a solid tumor or lymphoma in Gustave Roussy before 2000, included in the FCCSS cohort (French Childhood Cancer Survivor Study), aged >18 years and alive at the date of the LTFU Clinic opening (January 2012) were invited to a LTFU visit.
Article Synopsis
- Childhood cancer survivors often have more health problems as adults than others, which can make their healthcare costs higher.
- In France, a study looked at 5,353 people who survived cancer as kids to see how much more they spend on healthcare compared to others.
- The results showed that survivors spend about €3920 more a year, especially if they were treated before the 1990s or had brain tumors, while those who didn’t get radiation therapy spent less.
Risk factors for obesity in adulthood among survivors of childhood cancer.
Obesity (Silver Spring)
July 2023
Objective: The aim of this study was to identify risk factors for obesity in childhood cancer survivors (CCSs).
Methods: The study included 3199 patients of the French Childhood Cancer Survivor Study cohort, with 303 patients with obesity who had returned the self-questionnaire. Analyses were adjusted for social deprivation index and sex.
Article Synopsis
- Hospitalization rates indicate that childhood cancer survivors (CCS) face significantly higher risks related to renal and urinary diseases compared to the general population, particularly within 5 years post-treatment.
- The study analyzed data from a large cohort of CCS, revealing that these survivors have 2.9 times more renal-related hospitalizations, with specific treatments like high-dose ifosfamide increasing risks substantially.
- Findings emphasize the importance of long-term monitoring for renal health in CCS, especially for those with a history of nephrectomy or extensive radiation exposure.
The late effects of treatments for childhood cancers may lead to severe and multiple health conditions requiring hospitalisation. We aimed to estimate the hospitalisation rate among childhood cancer survivors (CCS) in France, to compare them with the general population and to investigate the associated factors. We matched total of 5439 5-year solid CCS diagnosed before the age of 21 between 1945 and 2000 by sex, birth year and region of residence to 386,073 individuals of the French general population.
View Article and Find Full Text PDFBackground: Published algorithms for identifying chronic kidney disease in healthcare claims databases have poor performance except in patients with renal replacement therapy. We propose and describe an algorithm to identify all stage chronic kidney disease in a French healthcare claims databases and assessed its performance by using data from the Renal Epidemiology and Information Network registry and the French Childhood Cancer Survivor Study cohort.
Methods: A group of experts met several times to define a list of items and combinations of items that could be related to chronic kidney disease.
Background: Compared with the general population, childhood cancer survivors (CCS) could be at greater risk of psychological distress following the emergence of the COVID-19 pandemic.
Purpose: This cross-sectional study assessed the psychological consequences of COVID-19 on the mental health of CCS.
Design And Participants: In December 2020, we interviewed through an online self-report questionnaire, 580 5-year CCS participating in the French Childhood Cancer Survivor Study (FCCSS) cohort.
Purpose: During the COVID-19 pandemic, childhood cancer survivors (CCS) may have felt more at risk of having severe consequences of COVID-19 and therefore may have been more likely to defer their health care use. We aimed to assess the risk perceptions of CCS related to COVID-19 (perceived infection risk, perceived risk of experiencing a severe illness in the event of infection), and their forgoing of health care during the year 2020.
Methods: In December 2020, we interviewed through an online self-report questionnaire 580 5-year CCS participating in the French Childhood Cancer Survivor Study (FCCSS) cohort.
Article Synopsis
- Intensive treatments with high-dose chemotherapy and stem cell rescue have improved survival rates for high-risk neuroblastoma (HRNB) patients, with a study following 145 survivors 15 years post-treatment showing promising long-term outcomes.
- However, the study revealed significant late effects, including late relapses and the development of second malignant neoplasms, indicating a need for ongoing monitoring and support for these survivors.
- Additionally, HRNB survivors experienced various non-cancer-related health issues, such as dental maldevelopment and organ-specific complications, with near-universal gonadal insufficiency noted in those treated with busulfan.
Article Synopsis
- Childhood cancer survivors (CCS) have an increased risk of heart failure (HF), yet how radiation affects heart volumes and their link to HF in this group is under-researched.
- A study analyzed data from 239 HF cases compared to 1,042 controls, finding that a significant portion of the heart receiving radiation (≥ 30 Gy) was associated with a higher HF risk, particularly in those who didn’t receive anthracyclines.
- This research establishes a connection between small irradiated heart volumes and HF risk, marking a new understanding that could improve clinical treatment practices for CCS.
Background: Very few previous studies have addressed the question of colorectal cancer (CRC) after childhood cancer treatment. We aimed to quantify the roles of radiation therapy and chemotherapy agents in the occurrence of subsequent CRC.
Methods: A nested case-control study was conducted using 36 CRC cases and 140 controls selected from 7032 five-year survivors of the French Childhood Cancer Survivor Study (FCCSS) cohort, treated from 1945 to 2000 in France.
Purpose: Male breast cancer (MBC) is uncommon, accounting for less than 1% of all breast cancers. Secondary breast cancers among childhood cancer survivors have been well described in the literature, but less is known about MBC.
Methods And Materials: We carried out an analysis in a cohort of 7019 five-year survivors of a solid childhood (aged ≤20 years) cancer treated in France before 2001 and followed for an average of 20 years and compared breast cancers occurring in both men and women.
Purpose: To describe fecundity in female survivors of childhood cancer and consider the correlation with quality of life (QOL).
Materials And Methods: Of 1744 women treated for childhood cancer before the age of 15 years at one of eight French cancer treatment centers between 1948 and 1992, 1187 who were alive in 2005 were sent a self-administered questionnaire, including questions about health status, QOL (MOS SF-36), and fecundity. A standardized fecundity ratio (SFR) was calculated (SFR: observed/expected number of children) for each individual based on a national reference.
Article Synopsis
- A study looked at how childhood cancer survivors face challenges when trying to get insurance for loans or mortgages.
- Out of 1,920 survivors, about 10% had problems getting small loans and over 30% had trouble with home loans, especially if they had to share their cancer history.
- A new law in France helps survivors by not requiring them to disclose their cancer after a certain number of years, which should make things easier for them financially.
Cerebrovascular Diseases in Childhood Cancer Survivors: Role of the Radiation Dose to Willis Circle Arteries.
Int J Radiat Oncol Biol Phys
February 2017
Background And Purpose: The aim of this study was to investigate the role of radiation dose received to the circle of Willis (WC) during radiation therapy (RT) and of potential dose-response modifiers on the risk of stroke after treatment of childhood cancer.
Methods: We evaluated the risk factors for stroke in a cohort of 3172 5-year survivors of childhood cancer who were followed up for a median time of 26 years. Radiation doses to the WC and brain structures were estimated for each of the 2202 children who received RT.
This study evaluated the prevalence of psychological distress (PD) in a cohort of 348 adult childhood cancer survivors with a very long-term follow-up and assessed the characteristics associated with this distress (cancer type, treatment, sex, age at diagnosis, self-reported late effects, social support, type of remembrance, time since the diagnosis, age at evaluation), assuming that with time since the diagnosis, the PD of survivors will approximate that of the general population. Before attending a long-term follow-up consultation, survivors were sent 3 questionnaires: the Brief Symptom Inventory-18, the Impact of Event Scale, and the Illness Worry Scale (IWS). During the visit, they were administered the Mini-International Neuropsychiatric Interview (MINI) by a psychologist.
View Article and Find Full Text PDFBackground: Although survival from childhood cancer has increased, little is known on the long-term impact of treatment late effects on occupational attainment or work ability.
Methods: A total of 3512 five-year survivors treated before the age of 19 years in 10 French cancer centres between 1948 and 2000 were identified. Educational level, employment status and occupational class of survivors were assessed by a self-reported questionnaire.
Importance: Few studies have been published on the association of the radiation dose received to the eyes during radiotherapy (RT) for childhood cancer and the risk for later cataract.
Objective: To investigate the risk for cataract after treatment of nonretinoblastoma solid cancer in childhood.
Design, Setting, And Participants: The study used data from the Euro2K cohort that includes 4389 5-year survivors of solid tumors treated from January 1, 1945, to December 31, 1985; of these, 3172 patients were treated in France.
Background: Cardiac disease (CD) is one of the major side effects of childhood cancer therapy, but until now little has been known about the relationship between the heart radiation dose (HRD) received during childhood and the risk of CD.
Methods And Results: The cohort comprised 3162 5-year survivors of childhood cancer. Chemotherapy information was collected and HRD was estimated.
Purpose: To prospectively assess the long-term toxicities of brachytherapy in female survivors with localized genital tract tumors.
Patients And Methods: The data concerning 42 patients treated at Gustave Roussy between 1971 and 2004, were both retrospectively and prospectively analyzed. Strictly confidential constructed surveys based on the LENT SOMA/SF-36v2 questionnaires were mailed and 51% were completed.
Context: Thyroid carcinoma is a frequent complication of childhood cancer radiotherapy. The dose response to thyroid radiation dose is now well established, but the potential modifier effect of other factors requires additional investigation.
Objective: This study aimed to investigate the role of potential modifiers of the dose response.