Beta-Alanine and Tris-(hydroxyl methyl) Aminomethane as Peak Modifiers in the Development of RP-HPLC Methods Using Aceclofenac and Haloperidol Hydrochloride as Exemplar Drugs.

In the present analytical approach, beta-alanine (ALA) and tris-(hydroxyl methyl) aminomethane (TRIS) were investigated as peak modifiers due to their water solubility and their possible peak modifying a property. These reagents were tested for their efficacy on the elution of aceclofenac (ACF) and haloperidol hydrochloride (HLC) from C18 column (250 mm × 4.6 mm, 5 μ) equipped with a photodiode array detector.

Direct utilization of industrial carbon dioxide with low impurities for acetate production via microbial electrosynthesis.

The present study aimed to demonstrate the utilization of unpurified industrial CO with low impurities for acetate production via microbial electrosynthesis (MES) for the first time. In MES experiments with CO-rich brewery gas, the enriched mixed culture dominated by Acetobacterium produced 1.8 ± 0.

Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation.

As part of an ongoing effort to develop new anti-tubercular agents, a series of novel indole-fused spirochromene hybrids (7a-l) were efficiently synthesized in excellent yields by the popular 'Fisher-Indole synthesis' approach. The structure elucidation of the target compounds was carried out by different spectral techniques including H-NMR, C-NMR, ESI Mass, and FTIR analysis. Additionally, the proposed structure of 7i was proved by single-crystal X-ray analysis.

Early prediction of clinical response in first episode schizophrenia (FES) patients receiving olanzapine.

At present, schizophrenia guidelines recommend waiting for 8 weeks before considering a patient as non-responder. This study aims to detect the optimal early response threshold that best predict the final outcome of olanzapine. The study was conducted for 8-week, four points follow up (week 2,3,4, and 8) prospective observational study.

Corkscrewing of retinal arterioles leading to diagnosis of coarctation of aorta.

Coarctation of aorta (CoA) usually leads to elevation of blood pressure above the site of obstruction and this elevated blood pressure probably gets transferred and is reflected in the retinal arterioles producing certain signs of hypertensive retinopathy. Fundus examination helps in differentiating hypertension due to CoA from other causes of juvenile hypertension, as corkscrewing of retinal arterioles is seen only in CoA but not in other conditions. A 16 year hypertensive male who was on antihypertensive treatment presented for routine checkup.

1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation.

A facile and convenient approach has been designed for the synthesis of novel prototypes that possess the advantage of the two pharmacophores of chromene and 1,2,3-triazole in a single molecular backbone, were evaluated against H37Rv strain. The new analogues 1,2,3-triazole-fused spirochromenes were accomplished in four step synthetic strategy utilizing click chemistry ([3 + 2] Huisgen cycloaddition) in the ultimate step. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 7a.

Self-sustained photocatalytic power generation using eco-electrogenic engineered systems.

An eco-electrogenic engineered system (EES) was designed to mimic the functional role of natural aquatic ecosystems and evaluated their response to bio-electrogenic activity by cascadically interlinking three tanks with functionally diverse biota viz., floating macrophytes (Tank 1), submerged plants (Tank 2) and filter feeders (fish and snails) (Tank 3). Tank 1 showed efficient power generation (voltage (series): 0.

Aripiprazole-induced transient myopia: A rare entity.

Aripiprazole is a new drug for the treatment of adults with schizophrenia. Ocular side effects of aripiprazole are very rare. Review of literature revealed few cases of aripiprazole-induced myopia.

Waste derived bioeconomy in India: A perspective.

Environmental and climatic change issues, population explosion, rapid urbanisation, depletion of fossil reserves, need for energy security, huge waste generation, etc. are some of the inherent issues associated with the fossil based linear economy which need greater attention. In this context, the world is gradually transforming from fossil-based economy to a sustainable circular bio-economy.

Diverse acidogenic effluents as feedstock for microalgae cultivation: Dual phase metabolic transition on biomass growth and lipid synthesis.

In this study, a biorefinery process integrating dark fermentation with microalgae cultivation (dual phase metabolic transition) was demonstrated with real-field wastewater. Acid rich fermented effluents (distillery waste (FDW1); dairy waste (FDW2)) were used as feedstock for microalgae cultivation. Experiments were performed with FDW1 during growth phase (GP) in mixotrophic mode and FDW2 during stress phase (SP) in both mixotrophic and heterotrophic modes.

Interval-Valued Model Level Fuzzy Aggregation-Based Background Subtraction.

In a recent work, the effectiveness of neighborhood supported model level fuzzy aggregation was shown under dynamic background conditions. The multi-feature fuzzy aggregation used in that approach uses real fuzzy similarity values, and is robust for low and medium-scale dynamic background conditions such as swaying vegetation, sprinkling water, etc. The technique, however, exhibited some limitations under heavily dynamic background conditions, as features have high uncertainty under such noisy conditions and these uncertainties were not captured by real fuzzy similarity values.

Polymorphisms of extrinsic death receptor apoptotic genes (FAS -670 G>A, FASL -844 T>C) in coronary artery disease.

Apoptosis plays an important role in atherogenesis and rupture of vulnerable plaques in coronary artery disease. FAS and FAS ligand (FASL) induce apoptosis when FAS binds to FAS-L. However sFas blocks apoptosis by binding to FAS and FASL or sFasL.

Neutral face classification using personalized appearance models for fast and robust emotion detection.

Facial expression recognition is one of the open problems in computer vision. Robust neutral face recognition in real time is a major challenge for various supervised learning-based facial expression recognition methods. This is due to the fact that supervised methods cannot accommodate all appearance variability across the faces with respect to race, pose, lighting, facial biases, and so on, in the limited amount of training data.

Evaluation of Hs-CRP levels and interleukin 18 (-137G/C) promoter polymorphism in risk prediction of coronary artery disease in first degree relatives.

Background: Coronary Artery Disease (CAD) is clearly a multifactorial disease that develops from childhood and ultimately leads to death. Several reports revealed having a First Degree Relatives (FDRS) with premature CAD is a significant autonomous risk factor for CAD development. C - reactive protein (CRP) is a member of the pentraxin family and is the most widely studied proinflammatory biomarker.

Implication of composite electrode on the functioning of photo-bioelectrocatalytic fuel cell operated with heterotrophic-anoxygenic condition.

Electrode materials play a vital role in biofilm formation and electron conduction for efficient functioning of fuel cells. In the present study, graphite polymer composite electrode (GPF) was evaluated as anode for photo-bioelectrocatalytic fuel cell (PhFC; biophotovoltaic system) and compared with much studied graphite electrode (Gc) with photosynthetic bacteria as biocatalyst under anoxygenic condition. The electrogenic activity noticed in GPF (584mV; 2.

Heterotrophic microalgae cultivation to synergize biodiesel production with waste remediation: progress and perspectives.

Microalgae are inexhaustible feedstock for synthesis of biodiesel rich in polyunsaturated fatty acids (PUFA) and valuable bioactive compounds. Their cultivation is critical in sustaining the global economy in terms of human consumption of food and fuel. When compared to autotrophic cultivation, heterotrophic systems are more suitable for producing high cell densities of microalgae for accumulation of large quantities of lipids (triacylglycerols) which can be converted into biodiesel.

Algal biocathode for in situ terminal electron acceptor (TEA) production: synergetic association of bacteria-microalgae metabolism for the functioning of biofuel cell.

Replacement of energy intensive mechanical aeration with sustainable oxygenic photosynthesis by microalgae at cathode was studied in dual-chambered microbial fuel cell (MFC). The synergistic association between bacterial fermentation at anode and the oxygenic photosynthesis of microalgae at cathode facilitated good power output as well as treatment efficiency. However, MFC operation during spring showed higher bioelectrogenic activity (57.

Bioaugmentation of potent acidogenic isolates: a strategy for enhancing biohydrogen production at elevated organic load.

The efficiency of bioaugmentation strategy for enhancing biohydrogenesis at elevated organic load was successfully evaluated by augmenting native acidogenic microflora with three acidogenic bacterial isolates viz., Bacillus subtilis, Pseudomonas stutzeri and Lysinibacillus fusiformis related to phyla Firmicutes and Proteobacteria separately. Hydrogen production ceased at 50g COD/l operation due to feed-back inhibition.

Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer.

Matrix metalloproteinases (MMPs) play an important role in breast cancer tumor invasion and progression. MMP-9 is a member of the MMP family and is also known as Gelatinase B or type IV collagenases (92 kDa) and possesses proteolytic activity against type IV collagen, a major component of the basement membrane. Our study aims to examine the association of Gelatinase B (-1562C > T) promoter polymorphism with breast cancer invasion and progression.

Neighborhood Supported Model Level Fuzzy Aggregation for Moving Object Segmentation.

We propose a new algorithm for moving object detection in the presence of challenging dynamic background conditions. We use a set of fuzzy aggregated multifeature similarity measures applied on multiple models corresponding to multimodal backgrounds. The algorithm is enriched with a neighborhood-supported model initialization strategy for faster convergence.