Publications by authors named "Chiranjeevee R Saravanan"
Objective: Giant cell arteritis (GCA) is a chronic inflammatory condition associated with a significantly increased risk of various cardiovascular and thromboembolic events. Existing studies suggest an increased risk of cardiovascular disease in GCA, but results vary. This meta-analysis aims to quantify the association between GCA and the risk of various cardiovascular outcomes, providing a comprehensive evaluation of the cardiovascular burden in patients with GCA.
View Article and Find Full Text PDFCardio-ankle vascular index (CAVI) is an innovative indicator of large-artery stiffness, which is evaluated by the pulse wave velocity (PWV) measurement. Mortality and morbidity due to cardiovascular diseases among the general public with high-risk conditions such as hypertension are usually associated with arterial stiffness. CAVI modelizes the hazard of future cardiovascular events with standard risk factors.
View Article and Find Full Text PDFArticle Synopsis
- - Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons, and there's a critical need for new therapies that can halt or reverse its progression, making gene therapy a promising option to explore.
- - A systematic review evaluated the safety and effectiveness of gene therapy in PD by analyzing studies from databases like PubMed and Cochrane, with an emphasis on bias assessment and the neuroprotective potential of these treatments, which could repair neuronal damage and improve brain circuit function rather than just alleviating symptoms.
- - The results suggest that gene therapy might offer advantages over traditional treatments, including reduced side effects, improved symptom relief, and more effective dopamine replacement; however, the need for more