Dynamic pH and Thermal Analysis of Paper-Based Microchip Electrophoresis.

Paper-based microchip electrophoresis has the potential to bring laboratory electrophoresis tests to the point of need. However, high electric potential and current values induce pH and temperature shifts, which may affect biomolecule electrophoretic mobility thus decrease test reproducibility and accuracy of paper-based microfluidic electrophoresis. We have previously developed a microchip electrophoresis system, HemeChip, which has the capability of providing low-cost, rapid, reproducible, and accurate point-of-care (POC) electrophoresis tests for hemoglobin analysis.

Assessment of body force effects in flow condensation, Part I: Experimental investigation of liquid film behavior for different orientations.

Body force effects in flow condensation vary depending on channel orientation and fluid mass velocity, making the design of systems intended to operate in multiple orientations more complicated than those at a fixed orientation. This study examines the effects of body force on liquid film development for flow condensation of FC-72 in horizontal, vertical upflow, and vertical downflow orientations. Two test sections are utilized, one capable of providing high-speed imaging of liquid film development, and the other designed to allow detailed measurements of flow condensation heat transfer coefficient.

Assessment of body force effects in flow condensation, part II: Criteria for negating influence of gravity.

This study concerns the development of a set of mechanistic criteria capable of predicting the flow conditions for which gravity independent flow condensation heat transfer can be achieved. Using FC-72 as working fluid, a control-volume based annular flow model is solved numerically to provide information regarding the magnitude of different forces acting on the liquid film and identify which forces are dominant for different flow conditions. Separating the influence of body force into two components, one parallel to flow direction and one perpendicular, conclusions drawn from the force term comparison are used to model limiting cases, which are interpreted as transition points for gravity independence.

Effects of two-phase inlet quality, mass velocity, flow orientation, and heating perimeter on flow boiling in a rectangular channel: Part 2 - CHF experimental results and model.

This study is the second part of a two-part study exploring flow boiling of FC-72 along a rectangular channel with either one wall or two opposite walls heated for saturated inlet conditions. While the first part examined flow boiling interfacial behavior, boiling curves, local and average heat transfer coefficients, and pressure drops, this part is focused entirely on CHF measurement, flow visualization and modeling. Both single-sided and double-sided heating configurations are tested in horizontal flow, vertical upflow, and vertical downflow.

Effects of two-phase inlet quality, mass velocity, flow orientation, and heating perimeter on flow boiling in a rectangular channel: Part 1 - Two-phase flow and heat transfer results.

Lack of understanding of flow boiling behavior in reduced gravity poses a major challenge to the development of future space vehicles utilizing two-phase thermal control systems (TCSs). A cost effective method to investigating the influence of reduced gravity on flow boiling is to perform ground experiments at different orientations relative to Earth gravity. This paper is the first part of a two-part study aimed at exploring flow boiling mechanisms of FC-72 in a rectangular channel heated along one wall or two opposite walls.

Time-averaged and transient pressure drop for flow boiling with saturated inlet conditions.

This study explores flow boiling pressure drop of FC-72 in a rectangular channel subjected to single-side and double-sided heating for vertical upflow, vertical downflow, and horizontal flow with positive inlet quality. Analysis of temporal records of pressure transducer signals is used to assess the influences of orientation, mass velocity, inlet quality, heat flux, and single-sided versus double-sided heating on magnitude of pressure drop oscillations, while fast Fourier transforms of the same records are used to capture dominant frequencies of oscillations. Time-averaged pressure drop results are also presented, with trends focusing on the competing influences of body force and flow inertia, and particular attention paid to the impact of vapor content at the test section inlet and the rate of vapor generation within the test section on pressure drop.