Publications by authors named "Chio Sakai"
Asthma is a heterogeneous disease that can be broadly classified into type 2, which is primarily steroid-sensitive and eosinophilic, and non-type 2, which is primarily steroid-resistant and neutrophilic. While the mechanisms leading to the development of molecular-targeted therapies for type 2 asthma are being elucidated, much remains to be learned about non-type 2 asthma. To investigate the role of oxidative stress in refractory allergic airway inflammation, we compared asthma models generated by immunizing wild-type and nuclear factor erythroid-2-related factor 2 (Nrf2)-deficient mice with the house dust mite antigen.
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- - The study aimed to identify risk factors for the progression of pulmonary Mycobacterium avium complex (MAC) disease in patients diagnosed via bronchoscopy who did not have culture-positive sputum.
- - An analysis of 93 patients revealed that 55.9% experienced clinical progression within four years, with no significant differences between progressed and stable groups in various health factors.
- - Key risk factors for progression included being male, having a monocyte to lymphocyte ratio (MLR) of 0.17 or higher, and having lesions in the middle (lingula) and lower lobes, indicating the need for careful monitoring of certain patients.
In recent years, the incidence and prevalence of pulmonary nontuberculous mycobacterial (NTM) disease have increased worldwide. Although the reasons for this increase are unclear, dealing with this disease is essential. Pulmonary NTM disease is a chronic pulmonary infection caused by NTM bacteria, which are ubiquitous in various environments.
View Article and Find Full Text PDFIntroduction: Ovarian granulosa cell tumor is a relatively rare tumor that accounts for 2-5% of malignant ovarian tumors. This tumor progresses slowly and may recur late in life.
Case Presentation: A 70-year-old woman was admitted to our hospital with a left secondary pneumothorax due to metastatic lung tumors of granulosa cell tumor.
A 24-year-old man with a history of bloody sputum for 6 months was referred to our hospital with suspected alveolar hemorrhaging due to vasculitis. Chest computed tomography showed ground-glass opacities in both lungs, and an examination of his bronchoalveolar lavage fluid showed alveolar hemorrhaging. However, no evidence of vasculitis was found, and subsequent polysomnographic testing confirmed that he had severe obstructive sleep apnea (OSA).
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- A 54-year-old man began taking oren-gedoku-to to relieve chronic symptoms like hot flashes, night sweats, and insomnia, but developed a high fever shortly after starting the treatment.
- After experiencing malaise and chills for 17 days, he stopped the medication and was hospitalized, where drug-induced pneumonitis was suspected.
- His condition improved after stopping all medications, and tests confirmed that the pneumonitis was caused by ougon, a component of oren-gedoku-to.