Copper-mediated nucleophilic radiofluorination of [ F]β-CFT for positron emission tomography imaging of dopamine transporter.

[ F]β-CFT is a positron emission tomography (PET) ligand for imaging of dopamine transporter. It was proved to be a sensitive PET marker to detect presynaptic dopaminergic hypofunction in Parkinson's disease. In recent years, copper-mediated F-fluorination of aryl boronic esters has been successful in some molecules containing aromatic groups.