Publications by authors named "Ching-Ying Lin"
Article Synopsis
- CNPY2 is significantly overexpressed in liver cancer (HCC) and its levels are linked to poor survival outcomes in patients.
- The deletion of Cnpy2 in mice prevents HCC development induced by a chemical carcinogen, showing its crucial role in liver cancer progression.
- CNPY2 contributes to p53 destabilization and promotes oncogene expression through its interaction with ribosome proteins and enhancement of UPR pathways, indicating it as a potential therapeutic target for HCC.
Metastatic castration-resistant prostate cancer (mCRPC) is an aggressive and fatal disease with a median survival of 36 months. With the advent of genetic sequencing to identify individual genomic profiles and acquired tumor-specific pathways, targeted therapies have revolutionized cancer treatment, including the treatment strategy in mCRPC. Poly(adenosine 5'-diphosphate) ribose polymerase inhibitors (PARPi) are oral drugs that target mutations in the homologous recombination repair (HRR) pathway, which are found in approximately 27% of prostate cancer patients.
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- Immunotherapy has become a standard treatment for certain advanced gastric cancers, but its effectiveness in resectable cases is still uncertain.
- A case study is presented where a man with resectable gastric cancer, characterized as microsatellite stable but positive for PD-L1 and Epstein-Barr Virus, received neoadjuvant treatment with pembrolizumab and capecitabine, largely due to the challenges posed by the COVID-19 pandemic.
- The patient experienced a complete response with no signs of disease afterward, suggesting that combining immunotherapy and chemotherapy could be a promising approach for treating resectable gastric cancer and highlighting the need for more research in this area.
Sex Differences in Using Systemic Inflammatory Markers to Prognosticate Patients with Head and Neck Squamous Cell Carcinoma.
Cancer Epidemiol Biomarkers Prev
October 2018
Remarkable discrepancy exists in outcomes between men and women for multiple malignancies. We sought to expose sex differences in using platelet count and neutrophil-to-lymphocyte ratio (NLR) to predict overall survival for select cancer types with focus on head and neck squamous cell carcinoma (HNSCC). Peripheral blood samples from 9,365 patients seen in a tertiary teaching hospital with nine different primary tumors were retrospectively examined.
View Article and Find Full Text PDFObjectives: The objective of this research was to develop ethics accreditation standards for hospitals.
Research Design: Our research methods included a literature review, an expert focus group, the Delphi technique and a hospital survey. The entire process was separated into two stages: (1) the development of a draft of hospital ethics accreditation standards; and (2) conducting a nationwide hospital survey of the proposed standards.