Improved iron utilization and reduced erythropoietin resistance by on-line hemodiafiltration.

Background: Recent investigation has shown that on-line hemodiafiltration (HDF) can reduce the amount of recombinant human erythropoietin (rhEPO) deemed necessary to reach the target hematocrit. The aim of this study was to analyze the potential effect of on-line HDF on rhEPO resistance in relation to iron utilization and anemia-related parameters, when compared to conventional hemodialysis (HD).

Methods: Ninety-two chronic uremic patients were treated with conventional HD and then shifted to on-line HDF.