Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy.

Proliferative diabetic retinopathy is a potentially blinding sequela of uncontrolled diabetes that involves a complex interaction of pro-angiogenic and inflammatory pathways. In this study, we compared the levels of pro-angiogenic arachidonic acid-derived mediators in human vitreous humor obtained from eyes with high-risk proliferative diabetic retinopathy versus controls. The results indicated that lipoxygenase and cytochrome P450-derived eicosanoids were elevated (5-HETE, 12-HETE, 20-HETE, and 20-COOH-AA) and there appeared to be no differences in levels measured in eyes with tractional retinal detachments versus those without.

Severe ocular trauma in the emergency room.

Unlabelled: To assess the nature, severity, and mechanisms of ocular trauma in the emergency room at an academic teaching hospital.

Methods: Individual review of patients' records involving ocular trauma in the emergency room. Severe intraocular trauma was defined as any injury that required intraocular surgery, any traumatic optic neuropathy, or total destruction of the eye.

Factors affecting wound leakage in 23-gauge sutureless pars plana vitrectomy.

Purpose: To evaluate risk factors for sclerotomy leakage in 23-gauge sutureless pars plana vitrectomy in 219 patients.

Methods: Nested case-control study involving 48 patients with wound leaks (visible on-table sclerotomy leakage requiring sutures) and 171 control subjects without wound leaks. Patients received either a conventional sclerotomy incision at 45°, which was then changed to 90° midincision, or an extremely oblique sclerotomy incision (OSI) at 10°, which was then changed to 30° midincision.