Publications by authors named "Chinelo H Okonkwo"
Despite improved treatment options, colorectal cancer (CRC) remains a huge public health concern with a significant impact on affected individuals. Cell cycle dysregulation and overexpression of certain regulators and checkpoint activators are important recurring events in the progression of cancer. Cyclin-dependent kinase 1 (CDK1), a key regulator of the cell cycle component central to the uncontrolled proliferation of malignant cells, has been reportedly implicated in CRC.
View Article and Find Full Text PDFPseudomonas aeruginosa is a major pathogen in humans and other animals, frequently harboring mechanisms of resistance to commonly used antimicrobials. Here, we describe the isolation of Pseudomonas bacteriophage Zikora. The full 65,837-bp genome was annotated and demonstrates similarity to phages, making Zikora a new member of this genus of the family.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the antiplasmodial effects of the leaf extract from Landolphia owariensis, traditionally used in southeast Nigeria for malaria treatment, on Plasmodium berghei-infected mice.
- Results showed significant suppression of parasitemia and improved survival rates in treated mice, with the methanol fraction demonstrating the highest antimalarial activity and low toxicity.
- The findings support the medicinal use of L. owariensis by identifying key phytochemicals like alkaloids and flavonoids responsible for its effectiveness against malaria.