Publications by authors named "Chinedum Eleazu"

Objective: The effect of methanol leaf extract (SMLE) on some parameters of testosterone-estradiol valerate induced benign prostatic hyperplasia (BPH) in rats was assayed.

Materials And Methods: Thirty male albino rats were used and they were grouped as: Control: received 1 mL/kg olive oil (oral and subcutaneous); BPH: received subcutaneously 9 mg/kg dihydrotestosterone (DHT)+0.9 mg/kg estradiol valerate (ESV) and orally 1 ml/kg olive oil; finasteride: received 9 mg/kg of DHT+0.

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Ethnopharmacological Relevance: Many ethnopharmacological properties (anti-tumor, etc.) have been credited to Plectranthus esculentus tuber but the scientific basis has not been established.

Aim Of The Study: To evaluate the effect of methanol extract of P.

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The effect of 21% fructose drinking water (FDW) (w/v) on some parameters of metabolic syndrome, hepatic, and skeletal muscular histology of rats was studied using standard techniques. Twenty male albino rats were divided into four groups of 5 rats each in this in vivo study. Group I received distilled water, group 2 received FDW, group 3 received FDW and metformin (300 mg/kg body weight daily, orally), group 4 received FDW and 1% tert-butylhydroquinone feed.

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The burden of ischemic heart disease in Nigeria calls for an evidence-based, innovative, and interdisciplinary approach towards decreasing health inequalities resulting from individual lifestyle and poor socioeconomic status in order to uphold the holistic health of individuals to achieve global sustainability and health equity. The poor diagnosis and management of ischemic heart disease in Nigeria contributes to the inadequate knowledge of its prognosis among individuals, which often results in a decreased ability to seek help and self-care. Hence, current policies aimed at altering lifestyle behaviour to minimize exposure to cardiovascular risk factors may be less suitable for Nigeria's diverse culture.

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The pituitary-gonadal axis plays an important role in steroidogenesis and spermatogenesis, and by extension, fertility. The aim of this study was to investigate the protective role of bee bread, a natural bee product, against obesity-induced decreases in steroidogenesis and spermatogenesis. Thirty-two adult male Sprague-Dawley rats weighing between 200 and 300 g were divided into four groups ( = 8/group), namely: normal control (NC), high-fat diet (HFD), HFD plus bee bread administered concurrently for 12 wk (HFD + B), HFD plus orlistat administered concurrently for 12 wk (HFD + O) groups.

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Doxorubicin (DOX) is a broad-spectrum chemotherapeutic drug used in the treatment of cancers. It acts by generating reactive oxygen species in target cells. The actions are, however, not limited to cancerous cells as it attacks healthy cells, killing them.

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The increased global prevalence of benign prostatic hyperplasia (BPH) and the promising potentials of functional foods in ameliorating it led to this study which reported the effect of aqueous ethanol extract of cocoyam () tuber on some biochemical indices in testosterone propionate (TP) induced benign prostatic hyperplasia (BPH) rats. Thirty male albino rats were randomly assigned into 6 groups of 5 rats each. Group 1 (negative control) received 3 mg/kg of TP and normal saline, group 2 (positive control) received 3 mg/kg of TP and 5 mg/kg of finasteride; groups 3, 4, and 6 rats received 3 mg/kg of TP and 100, 200 and 400 mg/kg of ethanol extracts of cocoyam respectively while group 5 (normal control) received olive oil + normal saline.

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The effect of bee bread (BB) on the biochemical parameters-body weights, calorie intake, Lee obesity indices, serum amylase, aspartate and alanine amino transferases, skeletal muscle activities of creatine kinase, superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, glutathione-S-transferase, total antioxidant activity, endogenous secretory receptor for advanced glycation end products (esRAGE), and muscle histology of high-fat diet (HFD) obese rats-was studied. Thirty-six male Sprague-Dawley rats were divided into six groups: Control: received rat feed and water (1 ml/kg); HFD: received HFD and water (1 ml/kg): BB or orlistat preventive: received HFD and BB (0.5 g/kg) or HFD and orlistat (10 mg/kg; weeks 1 to 12); BB or orlistat treated: received HFD and BB (0.

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Oxidative stress, chronic inflammation and apoptosis are associated with obesity. Herein, we investigated the potential protective effect of bee bread, a natural bee product, on testicular oxidative stress, inflammation and apoptosis, as well as lactate transport in the testis of high-fat diet (HFD)-induced obese rats. Adult male Sprague-Dawley rats were either fed with normal chow (NC), HFD, HFD + bee bread (0.

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Context: Global prevalence of obesity is increasing.

Objective: To study the effect of bee bread (BB) on serum renal function parameters, oxidative stress, inflammatory and B-cell associated protein X (Bax) in the kidneys of high fat diet (HFD) obese rats.

Methods: Thirty-six male Sprague Dawley rats were used.

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Oxidative stress, inflammation and apoptosis are major complications that trigger organ failure in diabetes mellitus (DM), and are proven to adversely affect the male reproductive system. Clinical and experimental studies have demonstrated the promising protective effects of propolis in DM and its associated systemic effects. Herein, we investigated the effect of Malaysian propolis (MP) on testicular oxidative stress, inflammation and apoptosis in diabetic rats.

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Article Synopsis
  • Tamoxifen (TAM), a breast cancer treatment since 1977, causes liver toxicity primarily through oxidative stress and inflammation, raising concerns for doctors.
  • A study on female Wistar rats showed that zinc supplementation could counteract TAM-induced liver damage by improving liver function markers and antioxidant levels.
  • Zinc effectively reduced inflammatory and apoptotic responses, suggesting it could be a helpful supplement for women receiving TAM therapy to minimize liver toxicity.
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Obesity, a chronic multifaceted disease, predisposes its patients to increased risk of metabolic disorders such as: diabetes mellitus, cardiovascular diseases, dyslipidemia, etc. Recent studies reported it to be amongst the leading causes of deaths in the world. Although several treatment options for obesity abound, many of them have not been able to successfully reverse the existing obesity and metabolic dysregulation.

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Unlabelled: Bentham Science has decided to withdraw this article from the journal in accordance with BSP Editorial Policies and apologizes to its readers for any inconvenience this may cause.

Bentham Science Disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained.

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Article Synopsis
  • Limited research exists on the effects of Virgin Coconut Oil (VCO) on diabetes in humans and animals.
  • The study aimed to analyze the impact of VCO on various health indicators in diabetic rats, including lipid profiles and liver/kidney functions.
  • Results indicated that while VCO did not significantly alter blood glucose or body weights, it positively influenced certain antioxidant activities and lipid markers in comparison to diabetic controls.
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The nutrients, heavy metals and pesticide concentrations of an imported (Gold) and three locally produced and marketed rice varieties (Samples B-mass, C-R8 and D-CP) in Nigeria were investigated using standard techniques. All the rice varieties contained considerable amounts of moisture, ash, protein, lipid and carbohydrate but were low in crude fibre. The local rice varieties contained higher (P < 0.

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The effect of ethanol extracts of boiled seed on the oral glucose tolerance (OGTT), lipid profile, and body weight of normoglycemic albino rats was determined. Fifteen male albino rats were used and were divided into three groups of five rats each. Groups 1 and 2 received 100 and 200 mg/kg of the extract, while group 3 (control group) received 1 ml/kg of normal saline.

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Article Synopsis
  • The prevalence of type 2 diabetes mellitus (T2DM) is rising, highlighting the need for new treatment options with fewer side effects compared to current oral medications.
  • Free fatty acid receptor 1 (FFAR1), which is activated by certain fatty acids and enhances insulin secretion, shows potential as a therapeutic target for T2DM.
  • Recent advancements in the development of novel FFAR1 agonists are promising for improving the management of T2DM with fewer adverse effects.
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Background: There is a paucity of information in the literature on the effect of Cnidoscolus aconitifolius on the hematological, coagulation activities, electrolyte balance and antioxidant activities of humans or animals.

Objectives: To determine the ameliorative potentials of methanol fractions of Cnidoscolus aconitifolius on hematological, coagulation, electrolyte, hepatic and renal antioxidant activities of streptozotocininduced diabetic rats using standard techniques.

Method: Thirty rats, distributed into five groups of six rats each were used for this study.

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Article Synopsis
  • The study examined how processing affects the biochemical makeup of leaves, reporting specific measurements of moisture, protein, and other components in both raw and processed forms.
  • Significant reductions in various nutrients and bioactive compounds were found in leaves after boiling or boiling followed by sun-drying, though some nutrients and carbohydrates increased with sun-drying alone.
  • Sun-drying improved the retention or release of beneficial compounds, and reduced moisture levels, which may enhance shelf life by making the leaves less hospitable to microorganisms.
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Article Synopsis
  • - The study examined how cooking affects the starch composition, polyphenol content, and α-amylase inhibitory properties of various food samples, including different types of mushrooms, sweet potatoes, and potatoes, revealing a wide range of starch digestibility levels.
  • - It found that raw and boiled potatoes and sweet potatoes demonstrated moderate to high inhibition of α-amylase, a digestive enzyme, while certain cooked samples activated the enzyme, indicating varied effects on starch digestion.
  • - The research highlighted a significant relationship between α-amylase inhibition and starch digestibility, suggesting that boiled potatoes and raw sweet potatoes could be beneficial for individuals with type 2 diabetes by potentially reducing starch absorption.
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Article Synopsis
  • The incidence of benign prostatic hyperplasia (BPH) is increasing, leading to a search for alternative treatments beyond conventional medications that have side effects.
  • Dietary polyphenols, known for their potential in disease prevention, have not been thoroughly investigated for their effects on BPH.
  • A literature review suggests that while polyphenols may not replace existing treatments, they show promise in contributing to BPH management and warrant further research.
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Background: Although African breadfruit (Treculia africana) is said to be useful in the dietary management of diabetes, the effect of cooking on its glycemic index has not been reported. Hence this study has investi- gated the effect of a dietary intake of boiled breadfruit on the serum glucose, glucose tolerance, body weights and relative organ weights of streptozotocin (STZ) induced diabetic rats.

Methods: Twenty albino rats were used and were divided into four groups of five rats.

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The incidence of erectile dysfunction (ED) is on the increase and it is estimated that it will affect about 322 million men globally by the year 2025 if adequate measures are not taken to curb it. Natural polyphenols in plant based diets have gained public interest in recent times due to their roles in the prevention of various disease that implicate free radicals/reactive oxygen species and recently on ED. However, the role of polyphenols in the management of ED has not been explored due perhaps to limited data available.

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