Cerebrovascular disease in sickle cell disease.

Sickle cell disease (SCD) is the most common type of hereditary anaemia and genetic disorder worldwide. Cerebrovascular disease is one of its most devastating complications, with consequent increased morbidity and mortality. Current guidelines suggest that children and adults with SCD who develop acute ischaemic stroke should be transfused without delay.

The Epidemiology of Neurological Complications in Adults With Sickle Cell Disease: A Retrospective Cohort Study.

Risk factors for neurological complications in sickle cell disease differ in the adult and pediatric populations. Here, we focused on neurological complications in adults with sickle cell disease. Patients were selected using the audit data from the St George's Hospital Red Cell Database.

Thiazolidinediones and associated risk of bladder cancer: a systematic review and meta-analysis.

Aims: To determine whether thiazolidinedione use is associated with a risk of bladder cancer.

Methods: We searched MEDLINE and EMBASE in June 2012 (with PubMed update to July 2013) and conducted meta-analysis on the overall risks of bladder cancer with pioglitazone or rosiglitazone and the risk with different categories of cumulative dose or duration of drug use.

Results: We screened 230 citations and included 18 studies, comprising five randomized controlled trials (RCTs) and 13 observational studies.