Publications by authors named "Chinedu A Akwuobu"

Objectives: In contrast to increasing reports of the emergence of linezolid-resistant enterococci (LRE) emanating from many countries in Europe, Asia, and North America, data on its status and dissemination from the African continent remain scarce, with the information available limited to countries in North Africa. This study investigated the carriage of LRE and the genetic mechanism of resistance among Enterococcus faecium and Enterococcus faecalis strains recovered from humans and animals in Makurdi, Nigeria.

Methods: We conducted a cross-sectional study between June 2020 and July 2021 during which 630 non-duplicate human and animal faecal samples were collected and processed for the recovery of LRE.

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Livestock, particularly pigs, have increasingly been recognized as important reservoirs for zoonotic transmission of pathogenic bacteria, including staphylococci. Livestock production systems in developing countries of sub-Saharan Africa, including Nigeria, are characterized by high misuse/abuse of antimicrobials and a close association between humans and these animals, which promotes the emergence and transmission of resistant and potentially virulent bacteria. In the present study, we investigated the occurrence and characteristics (species distribution, virulence and resistance profile) of staphylococci from smallholder backyard pig farms, slaughter slabs and pig handlers in Makurdi, Nigeria.

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This cross-sectional study was carried out to determine the common Gram-negative bacteria (GNB) contaminating veterinary clinic environments, and to evaluate the susceptibility of the isolates to commonly used antibiotics and biocides. A total of 62 swab samples were collected from different frequently touched surfaces in the 4 veterinary clinics visited. The samples were processed for isolation and identification of GNB using standard microbiological procedures.

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Article Synopsis
  • Resistance to critical antibiotics like carbapenem and colistin poses a major global health risk, as highlighted by a study involving 583 isolates from humans, animals, and the environment in Nigeria.
  • Among these isolates, 18.9% showed resistance to at least one type of carbapenem antibiotic, while 9.1% exhibited resistance to both carbapenems and colistin.
  • Whole genome sequencing revealed novel mutations linked to this resistance, indicating that both humans and animals in Nigeria could be crucial in the spread of these resistant bacteria, underscoring the need for increased research on antimicrobial resistance in Africa.
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Objective: The present study was initiated to ascertain the level of shedding of salmonellae by dogs in Makurdi area and to highlight the risk of infection for dog-owners.

Materials And Methods: Rectal swabs from 200 dogs from different locations in the study area were examined in the study. The samples were cultured for salmonellae using Rappaport-Vassiliadis enrichment broth (Oxoid) and brilliant green agar (Oxoid).

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The indicative prevalence of respiratory Mycoplasma species in small ruminants (SR) was determined in North-central Nigeria. Nasal swabs from 172 sheep and 336 goats from the Northeast, Northwest and South Senatorial Districts of Benue State were examined. Initial Mycoplasma isolation used Mycoplasma culture techniques followed by digitonin sensitivity testing.

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