Publications by authors named "Chinatsu Okachi"
Human SOD1 is secreted via a conventional secretion pathway in Saccharomyces cerevisiae.
Biochem Biophys Res Commun
July 2023
Article Synopsis
- Soluble proteins typically have an N-terminal signal peptide that guides them to the endoplasmic reticulum (ER) for translocation, but some proteins like SOD1, linked to amyotrophic lateral sclerosis (ALS), do not have this signal.
- Researchers found that SOD1 is still translocated into the ER using the translocon Sec61 and then secreted outside the cell.
- These findings suggest that targeting the secretion process of SOD1 could be a potential therapeutic strategy for treating ALS.