Publications by authors named "Chinatsu Aoki"

Bevacizumab plus paclitaxel therapy for recurrent breast cancer did not prolong overall survival(OS)in clinical trials, but it was efficacious for treating life-threatening HER2-negative recurrent breast cancer. This regimen is often used in daily clinical practice by breast surgeons. However, bevacizumab therapy results in unique adverse events, of which proteinuria and hypertension are relatively frequent.

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Article Synopsis
  • A 64-year-old man from Japan found a hard lump in his armpit, which turned out to be a rare type of breast cancer called a neuroendocrine tumor.
  • Doctors removed the tumor and nearby lymph nodes and discovered that most of the tumor was made up of neuroendocrine cells.
  • The man received additional treatments including chemotherapy, hormone therapy, and radiation to help fight the cancer.
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We assessed the feasibility of MR digital subtraction angiography (DSA) using parallel imaging and keyhole data sampling in the diagnosis of cerebrovascular diseases (CVDs) in 11 patients. Their diseases included arterial trunk stenosis/occlusion ( n=4), aneurysm ( n=3), arteriovenous malformation ( n=2), venous angioma ( n=1), and sinus thrombosis ( n=1). The technique depicted not only anatomical features, comparably to MR angiography ( n=10/11), but also hemodynamics such as collateral flow at a temporal resolution of 1.

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MR digital subtraction angiography (DSA) visualizes intracranial vasculature using a rapid T1-weighted sequence and a bolus injection of gadolinium. Although two-dimensional sequences are most frequently used, we applied a three-dimensional technique in combination with a fast method of k-space filling to improve both the temporal and spatial resolutions. In this preliminary study, we assessed the feasibility of using this technique for the diagnosis of brain tumors in 21 patients by reviewing the obtained images and, in 10 patients, comparing the images with conventional angiograms.

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We evaluated the feasibility of MR cisternography by the balanced fast-field-echo (bFFE) sequence, comparing with that by a turbo-spin-echo (TSE) sequence, for cerebellopontine angle lesions on a 1.5-T imager (Gyroscan Intera, Philips, Best, The Netherlands). The bFFE MR cisternograms depicted target cranial nerves with less cerebrospinal fluid pulsation artifacts than TSE cisternograms and visualized an acoustic schwannoma in 6 of 44 patients with suspicion and a causative vessel of hemifacial spasm in all of 3 patients in a short scanning time (1 min 53 s).

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We describe the diffusion-weighted (DW) MR imaging findings in three cases of spinal cord infarction using a recently developed single-shot fast spin-echo (SSFSE) technique. The SSFSE-DW MR images, which were obtained 20 hours, 3 days, and 18 days, respectively, after the ischemic event, demonstrated conspicuous areas of hyperintensity in the affected portions. Follow-up DW MR images, obtained in two of the patients at 17 days and 3 months, respectively, showed persistent decreased apparent diffusion coefficient values.

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The advent of a multi-detector row helical CT has made it possible to attain images over a broader area with good spatial resolution. We assessed whether postmyelographic CT scans obtained using this system provided more information than conventional imaging techniques. Postmyelographic CT scans were preoperatively obtained in 46 patients using a multi-detector row helical CT system.

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Purpose: The advent of multidetector-row computed tomography (MDCT) has enabled images with good spatial resolution to be obtained over a wide range in a short scanning time. Our purpose was to determine whether CT angiography using the MDCT system could effectively depict extracranial-intracranial (EC-IC) bypass routes.

Method: Helical CT angiography was performed using an MDCT scanner in 12 patients who had undergone EC-IC bypass surgery: 10 patients had undergone superficial temporal artery-middle cerebral artery (MCA) anastomosis, 1 patient had undergone an encephaloduroarteriosynangiosis procedure for the treatment of moyamoya disease, and 1 patient had undergone an external carotid artery-MCA anastomosis using a graft.

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