Substantia nigra nigrosome-1 imaging correlates with the severity of motor symptoms in Parkinson's disease.

Background: Nigrosome-1 imaging has been used for assisting the diagnosis of Parkinson's disease (PD). We aimed to examine the diagnostic performance of loss of nigrosome-1 in PD and the correlation between the size of the nigrosome-1 and motor severity of PD.

Methods: We included 237 patients with PD and 165 controls.