Overexpression of kappa-actin alters growth properties of hepatoma cells and predicts poor postoperative prognosis.

Unlabelled: Since Rho-mediated signaling can regulate liver cancer cell proliferation, amino acid sequence changes of its downstream targets, actins, might alter the properties of cell growth. Here, we investigated the function of a novel class of actins, named κ-actins, in hepatocellular carcinoma (HCC).

Materials And Methods: Alexander cells overexpressing an HCC-derived κ-actin (Alex-κ cells) were established to study growth property changes.