Publications by authors named "Chikwe J"

Objective: To characterize trends and outcomes of aortic valve replacement in patients <65 with aortic stenosis between 2013 and 2021.

Methods: This retrospective analysis included 9,557 patients who underwent biological aortic valve replacement in California, New York, and New Jersey from 2013 through 2021. Patients were stratified by approach: transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR).

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  • - Minimally invasive mitral valve repair techniques, including mini-thoracotomies and robotics, have greatly developed over the last 30 years, offering beneficial surgical options for patients.
  • - A study tracked 1,412 robotic mitral valve repairs from 2005 to 2023, showing significant improvements in surgical times and high repair success rates, particularly among patients treated by more experienced surgeons.
  • - Long-term results indicated a 92-93% survival rate at ten years and a very low rate of mitral regurgitation, demonstrating that robotic approaches provide effective and durable solutions for mitral valve issues.
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Background: Ex vivo lung perfusion (EVLP) may improve donor lung utilization but requires significant infrastructure and expertise. Centralized EVLP facilities may mitigate these requirements.

Methods: From the United Network for Organ Sharing database, we identified 345 adults undergoing isolated, first-time lung transplantation using donor lungs perfused by static EVLP (March 1, 2018-December 31, 2022).

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Background: Consensus guidelines recommend surgical aortic valve replacement (SAVR) over transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis aged ≤65 years. This analysis evaluates clinical practice and outcomes of TAVR and SAVR in patients aged ≤60 years.

Methods: We identified 2360 patients aged ≤60 years, including 523 TAVR (22.

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  • - The study analyzed outcomes of aortic repair techniques for descending thoracic aortic aneurysms (DTAAs) and thoracoabdominal aortic aneurysms (TAAAs) using data from The Society of Thoracic Surgeons Adult Cardiac Surgery Database, focusing on procedures from July 2017 to June 2022.
  • - Findings revealed that 85.2% of DTAA repairs were done endovascularly, while 66.9% of TAAA repairs were conducted through open surgery. Endovascular repairs showed lower rates of operative mortality, stroke, and spinal cord injury for both types of aneurysms compared to open repairs.
  • - The research suggested that differences in outcomes between the two surgical
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Background: Cardiogenic shock is a morbid complication of heart disease that claims the lives of more than 1 in 3 patients presenting with this syndrome. Supporting a unique collaboration across clinical specialties, federal regulators, payors, and industry, the American Heart Association volunteers and staff have launched a quality improvement registry to better understand the clinical manifestations of shock phenotypes, and to benchmark the management patterns, and outcomes of patients presenting with cardiogenic shock to hospitals across the United States.

Methods: Participating hospitals will enroll consecutive hospitalized patients with cardiogenic shock, regardless of etiology or severity.

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Tricuspid valve disease is an often underrecognized clinical problem that is associated with significant morbidity and mortality. Unfortunately, patients will often present late in their disease course with severe right-sided heart failure, pulmonary hypertension, and life-limiting symptoms that have few durable treatment options. Traditionally, the only treatment for tricuspid valve disease has been medical therapy or surgery; however, there have been increasing interest and success with the use of transcatheter tricuspid valve therapies over the past several years to treat patients with previously limited therapeutic options.

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  • Tricuspid valve annuloplasty (TA) during mitral valve repair (MVr) increases the risk of needing a permanent pacemaker (PPM) post-surgery, with a higher 90-day PPM implantation rate for MVr with TA (14.0%) compared to isolated MVr (7.7%).
  • This study analyzed data from New York and California between 2004 and 2019 to evaluate the long-term effects of PPM implantation on survival and complications like heart failure hospitalization and endocarditis.
  • Results indicated that PPM recipients had significantly reduced long-term survival and higher risks of heart failure hospitalizations and endocarditis, regardless of whether they underwent isolated MVr or MVr with TA.
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  • There is a significant lack of diversity among participants in cardiovascular trials, which undermines the generalizability of results and ultimately affects health outcomes across different populations.
  • The Cardiothoracic Surgical Trials Network (CTSN) has acknowledged this issue and initiated a plan to improve representation among both investigators and trial participants, especially focusing on gender and racial diversity.
  • Results from CTSN trials reveal disparities in enrollment, with efforts now aimed at addressing barriers to participation, enhancing awareness of social determinants of health, and implementing active recruitment strategies to ensure a more representative sample in future trials.
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Objective: Limited comparative data guide the decision between coronary artery bypass grafting and percutaneous coronary intervention for multivessel revascularization in ischemic cardiomyopathy. The study objective was to compare the long-term outcomes of coronary artery bypass grafting and percutaneous coronary intervention for ischemic cardiomyopathy.

Methods: Clinical registries from the New Jersey Department of Health linked to administrative databases were used to compare all-cause mortality, repeat revascularization, heart failure readmissions, myocardial infarction, and stroke using Cox proportional hazards and propensity matching with competing risk analysis in 5988 patients with ejection fraction 35% or less who underwent coronary artery bypass grafting (3673, 61.

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Background: Minimally invasive (MI) approaches to lung transplantation (LTx) offer the prospect of faster recovery compared to traditional incisions, however, little data exist describing the impact of surgical technique on early outcomes and analgesia use.

Methods: A prospectively maintained institutional registry identified 170 patients who underwent LTx between January, 2017 and June, 2022. Post-COVID acute respiratory distress syndrome, repeat, and multiorgan transplants were excluded (n = 27) leaving 37 MILTx and 106 traditional LTx patients.

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Background: Although many options exist for multivessel coronary revascularization, controversy persists over whether multiarterial grafting (MAG) confers a survival advantage over single-arterial grafting (SAG) with saphenous vein in coronary artery bypass grafting (CABG). This study sought to compare longitudinal survival between patients undergoing MAG and those undergoing SAG.

Methods: All patients undergoing isolated CABG with ≥2 bypass grafts in The Society of Thoracic Surgeons Adult Cardiac Surgery Database (2008-2019) were linked to the National Death Index.

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Objectives: We evaluated practice trends and 3-year outcomes of transcatheter edge-to-edge repair (TEER) and surgical repair for degenerative mitral regurgitation in the United States.

Methods: From the Centers for Medicare and Medicaid Services data (2012-2019), 53,117 mitral valve interventions (surgery or TEER) were performed for degenerative mitral regurgitation, identified by excluding rheumatic and congenital disease, endocarditis, myocardial infarction, cardiomyopathy, and concomitant or prior coronary revascularizations. Median follow-up was 2.

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  • The study investigated the utilization of aortic valve replacement procedures (TAVR/SAVR) among Medicare beneficiaries hospitalized for aortic stenosis, focusing on differences based on race/ethnicity.
  • The research found that Black, Hispanic, and Asian patients were significantly less likely to receive aortic valve replacement compared to White patients, despite similar mortality rates.
  • The findings suggest that there are underlying inequalities in access to treatment for aortic stenosis that need to be addressed to improve care for disadvantaged populations.
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  • The study compares outcomes of women with multivessel coronary artery disease who underwent either percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery between 2012 and 2018.
  • Results showed that PCI was linked to a higher risk of 6-year mortality and major adverse cardiac events compared to CABG, with higher rates of repeat revascularization.
  • The conclusion emphasizes that CABG surgery offers better long-term outcomes in terms of survival and reduced complications for women in this patient group.
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  • The study compares 3-year outcomes of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in patients over 65 with bicuspid aortic stenosis, using data from Medicare between 2012-2019.
  • After matching patients based on various characteristics, results showed similar mortality risk within the first 6 months for both procedures, but TAVR had a higher mortality risk from 6 months to 3 years.
  • TAVR also had a lower risk of heart failure readmissions in the first 6 months, but a significantly higher risk for heart failure from 6 months to 3 years, with similar long-term risks for valve reinter
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