Lovastatin alters TGF-β-induced epithelial-mesenchymal transition in porcine lens epithelial cells.

Purpose: To determine whether lovastatin affects the epithelial-mesenchymal transition (EMT) in porcine lens epithelial cells (LECs) induced by transforming growth factor-β (TGF-β).

Materials And Methods: Porcine LECs were cultured in Dulbecco's Modified Eagle Medium (DMEM) for 24 h. The cultured cells were then exposed or not exposed to lovastatin (10 µM) for 18 h and then stimulated with or not stimulated with TGF-β2 (5 ng/ml) for 24 h.