Publications by authors named "Chikako Kaneko"
Cerebral amyloid angiopathy-related inflammation is a rare encephalopathy characterized by inflammation against amyloid protein accumulated in cerebral small vessels. A 50-year-old man was presented with a subacute consciousness disorder. Brain MRI revealed high intensity lesions in the white matter of the right parietal and occipital lobes on fluid-attenuated inversion recovery sequences and cerebral microbleeds in the right parietal and occipital lobes on T2*-weighted images.
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- Tick-borne encephalitis (TBE) is a serious central nervous system infection caused by the tick-borne encephalitis virus (TBEV), primarily found in Europe and Asia.
- In Japan, 5 confirmed cases have been reported, all on the northern island of Hokkaido, but evidence suggests TBEV could be more widespread, with possible undiagnosed infections in other regions.
- A study screened 520 patients with encephalitis or meningitis for TBEV antibodies, confirming 3 cases, highlighting the need for better awareness and diagnostic testing for TBE in Japan.
Background: Nutritional epidemiology has shown that inadequate dietary protein intake is associated with poor brain function in the elderly population. The plasma free amino acid (PFAA) profile reflects nutritional status and may have the potential to predict future changes in cognitive function. Here, we report the results of a 2-year interim analysis of a 3-year longitudinal study following mild cognitive impairment (MCI) participants.
View Article and Find Full Text PDFF-Fluorodeoxy Glucose and C-Methionine Accumulation in Demyelinating Lesions.
World J Nucl Med
December 2022
Few studies have evaluated the accumulation of F-fluorodeoxyglucose (FDG), C-methionine (MET), and other positron emission tomography (PET) tracers in patients with demyelinating disease. This study aimed to investigate the accumulation of FDG-PET/computed tomography (CT) and MET-PET/CT in demyelinating lesions. A retrospective search of the patient database in our hospital identified five patients with demyelinating disease in whom PET studies performed in the past 10 years revealed accumulation of FDG or MET.
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- McLeod syndrome is a rare genetic disorder characterized by neurological symptoms like chorea, cognitive issues, and muscle weakness, linked to mutations in the XK gene.
- A 66-year-old man with McLeod syndrome showed significant neurological symptoms, including muscle weakness and gait disturbances, alongside MRI findings of brain atrophy.
- This case represents the first findings indicating central sensorimotor tract involvement specifically in the legs of a McLeod syndrome patient, highlighting the need for further investigation of these pathways despite existing neuropathy symptoms.
A 26-year-old, 17-week pregnant woman developed aquaporin-4-IgG-positive severe longitudinally extensive transverse myelitis during the course of disseminated herpes zoster and became quadriparetic. She was unresponsive to high-dose intravenous methylprednisolone but became able to walk without assistance after intravenous immunoglobulin. One and a half months later, left optic neuritis developed but her vision improved with intravenous immunoglobulin.
View Article and Find Full Text PDFFive consecutive cases of anti-NMDA-receptor encephalitis that we encountered were marked by a rapidly fluctuating level of consciousness associated with psychotic and delirious mental states. Opisthotonus, catatonia, and rhythmic and non-rhythmic involuntary movements of the mouth and jaw were also characteristic features of these particular cases. Serious and potentially fatal problems included epilepsia partialis continua, partial and generalized seizures, and respiratory depression, resembling the symptoms of encephalitis lethargica.
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- - The study aimed to identify various clinical and social factors that delay early treatment for stroke patients in a northern Japan hospital, focusing on how quickly patients arrived after stroke onset.
- - Out of 287 patients, the median time to hospital presentation was 12 hours, with only 16.7% arriving within 2 hours; factors like a higher Japan Coma Scale score and cardiogenic cerebral embolism were linked to earlier hospital visits.
- - The findings suggest that most patients take too long to seek treatment, highlighting the importance of encouraging quicker hospital visits after stroke onset, particularly since severe symptoms lead to faster presentation.
Article Synopsis
- - The study compared care-needs certification rates between participants and non-participants in a geriatric health exam for seniors aged 70 and older in Japan over three years, involving 1347 adults initially.
- - Out of 838 subjects tracked, non-participants had a higher rate of dependency and poorer health conditions, with 16% receiving care-needs certification versus 7% among participants.
- - The findings indicate non-participants face greater health risks, suggesting a need for improved outreach and data collection for seniors who don't take part in health examinations.
The purpose of this research is to establish a scale for comfort with regard to whole-body vibration by the category judgment method. Experiments were conducted with random signals as stimuli. These stimuli consisted of three types of signal, namely stimulus F, with flat PSD (Power Spectrum Density) ranging from 1 to 100 Hz, stimulus H with PSD, which became 20 dB higher at 100 Hz than at 1 Hz, and stimulus L that had a PSD 20 dB lower at 100 Hz.
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