Publications by authors named "Chika Shimada"
Visible-Light-Driven Hydrogen Release from Dye-Sensitized Hydrogen Boride Nanosheets.
ACS Appl Mater Interfaces
July 2024
Article Synopsis
- Hydrogen boride (HB) nanosheets are considered lightweight and safe hydrogen carriers due to their high hydrogen density (8.5 wt %) and ability to release hydrogen when exposed to light.* -
- The study introduces dye-modified HB nanosheets that can generate hydrogen using visible light (over 470 nm), eliminating the need for heat, by allowing electron transfer from excited dye molecules.* -
- While the hydrogen production decreases over time due to dye oxidation, enhancing the process with agents like iodine ions and formic acid can sustain hydrogen generation from these nanosheets for longer periods.*
NF-kappaB is a transcription factor that induces the expression of inflammatory cytokines and antiapoptotic proteins. Earlier we designed a new NF-kappaB inhibitor, (-)-DHMEQ, and showed that it had potent anticancer and anti-inflammatory activities in various animal models without any toxicity. In the present research, we studied whether (-)-DHMEQ could be efficiently taken by cultured cells and irreversibly inhibit NF-kappaB by short time application to cultured cells.
View Article and Find Full Text PDFA new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ.
Bioorg Med Chem Lett
October 2010
The amino-epoxyquinols 6a and 6b were synthesized as soluble derivatives of an NF-κB inhibitor DHMEQ (1). In spite of the opposite configuration from 1, 6b rather than 6a affected the deactivation of NF-κB, based on NO secretion and MALDI-TOF MS analysis. It was indicated that 6b inhibited the activation by different manner from that of 1.
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