Secondary metabolites of endophytic fungi from Newbouldia laevis and Cassia tora leaves: prospecting for new antimicrobial agents.

Aim: This study tries to prospect for new antimicrobial agents using some Nigerian plants Background: Antimicrobial compounds from fungi endophytes have shown great promise in mitigating the threats of resistant pathogens.

Objective: The study evaluated the in vitro antimicrobial property of secondary metabolites of endophytic fungi isolated from Newbouldia laevis and Cassia tora leaves.

Methods: Ten endophytic fungi were isolated from the two plants' leaves and later fermented on local rice for 21 days.

Herb drug interaction: effect of Manix® on pharmacokinetic parameters of pefloxacin in rat model.

Objective: To evaluate the effect of Manix®, the commonly used polyherbal formulation on pefloxacin pharmacokinetic parameters.

Methods: Microbiological assay was employed using clinical isolate of Escherichia coli samples from hospitalized patients.

Results: Manix® altered the bioavailability parameters of pefloxacin as thus, maximal concentration (Cmax) of pefloxacin (0.