Publications by authors named "Chika Asai"
Article Synopsis
- Caveolin-1 (CAV-1) is a protein that inhibits various kinases and regulates inflammation, and its downregulation in psoriatic skin cells increases inflammation and cell growth.
- A study found that a peptide derived from CAV-1, called sB, was more effective than other modified peptides at reducing symptoms in a psoriasis model, improving skin condition and reducing immune cell infiltration.
- sB not only suppressed signaling pathways associated with inflammation but also inhibited new blood vessel formation, making it a promising therapeutic option for treating psoriasis.
Article Synopsis
- * A study of 79 PPP patients found that their neutrophil-to-lymphocyte ratio (NLR) was notably higher compared to healthy individuals, indicating a potential link between PPP and focal infections.
- * The research suggests that an NLR of 2.28 or above could serve as a biomarker for identifying focal infections in PPP patients, with NLR levels dropping after symptom improvement.
Psoriasis is a systemic, chronic, immunologically-mediated disease affecting approximately 2%-4% of the worldwide population. It is well known that psoriasis is associated with several comorbidities such as metabolic syndrome, cardiovascular disease, and malignancy. Although meta-analyses and large prospective cohort studies have shown an increased risk of malignancies in patients with psoriasis worldwide, an association between psoriasis and malignancy onset has not yet been established in Japan.
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- A study investigated cases of allergic contact dermatitis (ACD) caused by the skin adhesive Dermabond®, focusing on its clinical characteristics.
- Out of 577 patients tested, nine reacted positively to Dermabond®, with a notable difference in the onset timing of ACD symptoms based on whether it was their first or second use of the product.
- The findings revealed that most patients experienced primary sensitization to Dermabond® after their first exposure and exhibited frequent cross-reactivity to other cyanoacrylate adhesives.
Toxic epidermal necrolysis (TEN) is a rare condition, causing life-threatening adverse cutaneous reactions. TEN occurrence after bone marrow transplantation (BMT) is a well-known phenomenon; however, to date, only a few cases have been reported in the published work. Here, we describe the case of a 53-year-old woman who experienced TEN after undergoing allogenic BMT for malignant lymphoma.
View Article and Find Full Text PDFPegylated liposomal doxorubicin (PLD) is an anthracycline anticancer agent used in ovarian cancer and a form of doxorubicin enclosed in pegylated liposomes. There are only a few reports on intertrigo-like eruptions caused by PLD. We describe the first case of severe bullous erythema, including intertrigo-like eruptions with angioedema, induced by PLD in Japan.
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