Publications by authors named "Chiho Yabuta"
In Silico Ocular Pharmacokinetic Modeling: Delivery of Topical FK962 to Retina.
J Ocul Pharmacol Ther
September 2017
Article Synopsis
- The study aimed to create a computer-based model to understand how the eye drop FK962 behaves in the eye, specifically for treating choroid/retinal diseases.
- It involved testing FK962 in rabbits and measuring how well it moves through different layers of the eye, as well as its effect on retinal cells.
- The results showed that the model accurately predicts drug concentrations in the eye and suggests an effective dosing schedule for FK962, which could be beneficial for clinical trials focusing on retinal health.
Article Synopsis
- The study focused on the prevalence of dry eye syndrome (DES) among a young population undergoing LASIK surgery, finding that only 2% had obvious DES before surgery.
- A surprising 25% of patients labeled as Pre-DES showed low tear flow rates but were not classified as having DES, indicating potential underdiagnosis.
- The findings suggest that young LASIK patients could be at risk for serious complications due to inadequate tear production and may require tailored dry eye treatments post-surgery.
Article Synopsis
- - The study investigates the effect of the drug FK962 on the growth of nerve cells from the trigeminal ganglion, specifically looking at its ability to stimulate neurite elongation and regeneration after trigeminal nerve amputation.
- - Methods included culturing mixed trigeminal ganglion cells with FK962, using immunocytochemistry to observe neurite growth, and testing the release of specific factors like GDNF (glial cell line-derived neurotrophic factor) that are involved in nerve regeneration.
- - Results indicated that FK962 promotes neurite elongation by increasing GDNF production, suggesting that GDNF plays a role in the neurite regeneration process stimulated by FK962 in rat trigeminal neurons.
Article Synopsis
- The study investigated the effects of FK962, a drug, on nerve growth and recovery of corneal sensitivity in rabbits after creating a corneal flap.
- FK962 was found to promote nerve elongation in lab cultures and significantly improved axonal regeneration and sensitivity in the corneas of treated rabbits compared to untreated ones.
- The findings suggest that FK962 could potentially reduce complications for patients undergoing LASIK surgery by enhancing corneal re-innervation and sensitivity recovery.