Publications by authors named "Chihiro Okoshi"
The effect of smoking on hypertensive disorders of pregnancy is a public concern. Recent evidence suggests that the risk of hypertensive disorders of pregnancy is influenced by the presence of uterine fibroids. We explored the association between maternal smoking exposure and the risk of hypertensive disorders of pregnancy in relation to the presence of uterine fibroids using data from Japan's largest birth cohort study.
View Article and Find Full Text PDFTargeted metabolomic analysis of early-trimester serum identifies potential mechanisms for late-onset preeclampsia.
J Matern Fetal Neonatal Med
December 2024
Article Synopsis
- Preeclampsia (PE) is a pregnancy-related high blood pressure issue, and late-onset (Lo)-PE can lead to serious risks for both mothers and children, prompting a study to find biomarkers related to it through maternal serum analysis in the first trimester.
- The research involved 12 Lo-PE patients and 12 healthy pregnant women, using advanced techniques to identify charged metabolites in their serum samples.
- The findings revealed that glucosamine levels were higher and serotonin levels were lower in the Lo-PE group, suggesting these could be early indicators of Lo-PE, and highlighting the importance of diet and mental health in pre-pregnancy care to potentially prevent its occurrence.
Objectives: Hypertensive disorders of pregnancy (HDP) are a significant cause of morbidity and mortality. This study aimed to investigate whether preconception dietary fiber intake is associated with new-onset HDP.
Study Design: We identified 84,873 (primipara, 33,712; multipara, 51,161) normotensive participants from the Japan Environmental Children's Study database who delivered between 2011 and 2014.
Article Synopsis
- Women with polycystic ovary syndrome (PCOS) have a higher risk of gestational diabetes mellitus (GDM), particularly depending on their pre-pregnancy body mass index (BMI).
- A study in Japan assessed this risk using data from nearly 93,000 singleton pregnancies, finding that women with PCOS showed increased GDM risk mainly in those with higher BMI (G4 and G5 categories).
- The findings indicate that understanding the relationship between PCOS and BMI can help tailor preconception counseling for women at risk for GDM.
Article Synopsis
- Preterm birth (PTB) is a major cause of health issues in newborns, prompting this study to investigate the link between preconception dietary fiber intake and PTB risk.
- The study analyzed data from 85,116 pregnancies in Japan, categorizing participants into five groups based on their fiber intake before conception and using logistic regression to assess the relationship with PTB.
- Results indicated that higher dietary fiber intake (especially in the third, fourth, and fifth groups) was associated with a lower risk of PTB before 34 weeks, suggesting that improving dietary fiber intake could be beneficial as part of preconception care.
Article Synopsis
- Von Willebrand disease (VWD) is a bleeding disorder linked to issues with the von Willebrand factor, which is important for blood clotting.
- A case study focused on a 39-year-old woman with type 2A VWD who experienced delayed bleeding after surgery for endometrial polyps.
- Despite short-term treatment with VWF concentrate before and after surgery to prevent bleeding, the patient faced rebleeding on postoperative day 6, highlighting the need for careful monitoring and potential extended treatment.
Landscape of somatic mutated genes and inherited susceptibility genes in gynecological cancer.
J Obstet Gynaecol Res
November 2023
Article Synopsis
- Gynecological cancers have typically been categorized by their histology, but advancements in next-generation sequencing have allowed for the identification of somatic mutations and the genomic profiles of these cancers.
- Recent genomic profiling tests can detect numerous genetic mutations from cancer tissues or blood, aiding in diagnostics and treatment, while also identifying hereditary cancer-related variants.
- Approximately 5% of endometrial and 20% of ovarian cancers are linked to genetic factors, with major hereditary syndromes like Lynch syndrome and Hereditary breast and ovarian cancer syndrome being associated with these malignancies.
Article Synopsis
- Oocyte retrieval, a procedure in assisted reproductive technology, can lead to rare but severe complications like hemoperitoneum, which can require hospitalization and may be life-threatening.
- In this case, a 39-year-old woman experienced significant blood loss after her retrieval procedure due to a violent cough that occurred while a needle was inside her ovary.
- Subsequent medical imaging revealed a large hematoma, necessitating laparoscopic surgery to manage extensive bleeding from a tear in the ovarian tissue.