Publications by authors named "Chihiro Morizono"
Article Synopsis
- * In this study, researchers used mice models with varying levels of TROP2 expression to analyze the effects of a new ADC, TROP2-eribulin, focusing on its distribution and pharmacokinetics in tumor and lung tissues.
- * The findings indicated a higher concentration of released eribulin in tumors with high TROP2 expression and revealed that the uptake of TROP2-eribulin by alveolar macrophages in the lungs is linked to ILD, which could inform safer ADC development.
Hypoxic regions in solid tumors are highly resistant to drugs and thus represents an obstacle in drug discovery. Currently, however, there are technical barriers in sampling human hypoxic tumors and examining drug delivery with high sensitivity and accuracy. Herein, we present a new platform combining functional endoscopy and highly sensitive liquid chromatography-mass spectrometry (LC-MS) to assess drug delivery to hypoxic regions.
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