Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability.

Background: Skin fibroblast heterogeneity is of growing interest due to its relevance in not only skin development but also cutaneous wound healing. However, the characterization of human dermal fibroblasts at a clonal level has not been accomplished and their functional heterogeneity remains poorly understood.

Objective: The aim of this study was to define the clonal heterogeneity of human dermal fibroblasts.