Publications by authors named "Chiharu Iwahashi"
Introduction: Congenital X-linked retinoschisis (XLRS) presents as macular retinoschisis/degeneration in almost all patients and as peripheral retinoschisis in half the patients. Although the optical coherence tomography (OCT) findings of macular retinoschisis have been well investigated, those of peripheral retinoschisis have rarely been reported. This study aimed to report the ultra-widefield OCT findings of the peripheral retina in patients with XLRS.
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- A case study reported the successful use of adalimumab to treat bilateral retinal vasculitis in a patient with SAPHO syndrome, characterized by joint and skin symptoms.
- A 48-year-old woman experienced blurred vision due to retinal issues that did not improve with steroid eye drops, leading to the diagnosis of bilateral intermediate uveitis.
- After five months of adalimumab treatment, both her inflammatory markers and retinal condition showed significant improvement, marking a novel use for this medication in her specific syndrome.
This study evaluated the long-term visual outcomes of patients in whom at least one eye underwent successful lens-sparing vitrectomy (LSV) for stage 4A retinopathy of prematurity (ROP). A retrospective chart review was conducted using the data of 61 eyes of 42 patients with a minimum 4-year follow-up after successful LSV, with or without anti-vascular endothelial growth factor (VEGF) therapy, and whose best-corrected visual acuity (BCVA) was measurable using Landolt rings at the final visit. The mean age at the final follow-up was 10.
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- The study reported on ocular inflammatory events that occurred after COVID-19 vaccination in Japan, focusing on a case series from 16 hospitals with uveitis clinics.
- A total of 37 patients experienced these events, with a mean age of 53.4 years and symptoms appearing about 6.3 days post-vaccination, most commonly associated with the Pfizer-BioNTech vaccine.
- The findings suggest that healthcare providers should be aware of the potential for these inflammatory reactions as an adverse effect of COVID-19 vaccination.
Purpose: To present the clinical characteristics, surgical outcomes, and surgical complications of patients with congenital X-linked retinoschisis who underwent vitrectomy for bullous schisis cavity hanging over or threatening the macula.
Methods: Nine patients with congenital X-linked retinoschisis (12 eyes) who underwent vitrectomy at three tertiary hospitals and completed ≥3 years of postoperative follow-up were retrospectively investigated. Data were collected from patients' charts, including age at vitrectomy, surgical procedures, and postoperative complications.
Article Synopsis
- This study explored the success of vitrectomy procedures for Stage 5 retinopathy of prematurity (ROP), which has three subgroups according to updated classification.
- A retrospective analysis of 54 eyes from 34 patients showed that complete retinal reattachment was significantly higher in Stage 5A compared to Stage 5B, while Stage 5C had inoperable cases.
- The findings suggest that proper staging before surgery predicts the chances of successful reattachment, and using intravitreal bevacizumab during the procedure may lower the risk of complications post-surgery.
Background: We investigated the incidence and clinical characteristics of eyes showing retinal detachment (RD) after anti-vascular endothelial growth factor (VEGF) for retinopathy of prematurity (ROP).
Methods: A retrospective chart review of 76 consecutive eyes of 45 patients (18 girls and 27 boys) with stage 3 ROP who received anti-VEGF therapy between January 2012 and August 2020 with a minimum follow-up of 6 months was conducted. Eyes were divided into two groups: the vitrectomy (V) group that required vitrectomy for RD after anti-VEGF therapy and the non-vitrectomy (non-V) group that did not require vitrectomy.
Purpose: To report the outcomes of two only seeing eyes of two cases with retinoblastoma in which vitrectomy was performed to treat vitreous hemorrhage or rhegmatogenous retinal detachment after treatment for retinoblastoma.
Observations: Case 1 was an 8-month-old girl whose bilateral retinoblastoma (group D, OU) was treated by chemotherapy and focal ablation therapy. As the tumor size increased, enucleation was required in the right eye.
Article Synopsis
- The study aims to explore the relationship between diffuse large B-cell lymphoma lesions in the central nervous system (CNS) and patients with vitreoretinal lymphoma (VRL) over an extended period.
- Conducted as a multicenter, retrospective observational research, it included 71 patients, focusing on those newly diagnosed with VRL and CNS involvement.
- Results indicated that over 60% of VRL patients had CNS lesions, predominantly in forebrain and hindbrain tissues, with no significant link to optic pathways, emphasizing the need for careful evaluation of CNS lesions in these patients.
Purpose: To investigate the clinical characteristics of central serous chorioretinopathy (CSC) with age.
Study Design: Retrospective, cross-sectional study.
Methods: One-hundred and forty-seven CSC patients were classified into three age groups (aged <50 years (younger group; n=53), 50-70 years (middle group; n=68), and >70 years (senior group; n=26)) and the characteristics were compared.
Purpose: To investigate the efficacy and risk factors of intravitreal antivascular endothelial growth factor injection (anti-VEGF therapy) for retinopathy of prematurity (ROP).
Methods: We retrospectively reviewed 80 consecutive eyes of 43 patients with Type 1 ROP or worse who received anti-VEGF therapy during January 2012-February 2018. Patients were divided into those who were injected with 0.
Article Synopsis
- The study aimed to evaluate the occurrence and influencing factors of lens opacity in patients who underwent lens-sparing vitrectomy (LSV) for retinopathy of prematurity (ROP).
- It included a retrospective analysis of 108 eyes from 71 patients who had LSV between 2006 and 2019, focusing on lens status and related outcomes over a minimum of 12 months post-surgery.
- The findings indicated that 15.7% of eyes developed lens opacity, with 9.3% requiring lensectomy, and identified that younger postmenstrual age at surgery and tamponade use during LSV were significant risk factors for developing opacity.
Article Synopsis
- Subtenon injection of triamcinolone acetonide (STTA) is commonly used in ophthalmology, but there have been rare cases of orbital abscesses linked to this procedure, particularly involving fungal infections from Exophiala species.
- A 69-year-old diabetic woman developed a rare fungal orbital abscess from E. dermatitidis four months after receiving STTA for macular edema, which was treated successfully with surgery and antifungal medication.
- This case highlights the potential risk of fungal infections following STTA, especially in diabetic patients, and emphasizes the importance of monitoring for such complications after the procedure.
Purpose: To evaluate the 24-month effectiveness of polypoidal lesion-selective photodynamic therapy (PDT) combined with antivascular endothelial growth factor (VEGF) therapy for polypoidal choroidal vasculopathy (PCV) with branching vascular networks (BVNs) involving the fovea with 1 or more polyps.
Study Design: A retrospective case series.
Patients And Methods: Twenty-six eyes from 25 PCV patients treated with polypoidal lesion-selective PDT combined with aflibercept were included in the study.
Article Synopsis
- The study documents four cases where patients developed new or worsened uveitis after receiving infliximab treatment.
- The patients included three women with a mean age of 33, and they were treated for various conditions like rheumatoid arthritis and Crohn’s disease.
- All cases saw improvement in ocular inflammation after discontinuing infliximab and adding other treatments, suggesting that these adverse effects are rare but significant.
Purpose: This study evaluated the long-term visual prognosis of a serous retinal detachment (SRD) secondary to tilted disc syndrome with or without an SRD at the final visit and the interventions.
Design: A retrospective, observational case series.
Methods: This was a multicenter study with an enrollment of 48 eyes of 41 treatment-naïve patients (14 men, 27 women) in whom tilted disc syndrome-related SRD was diagnosed at the first visit.
We report a case of eosinophilic chronic rhinosinusitis (ECRS) associated with choroidal folds and ocular motility disorder. A 50-year-old male with rhinosinusitis and bronchial asthma presented with anorthopia of the lower visual field and ocular motility disorder of the left eye. Dilated fundus examination and optical coherence tomography (OCT) revealed wavy choroidal folds in the upper retina.
View Article and Find Full Text PDFWe investigated the rates of the use of steroids in Japanese central serous chorioretinopathy (CSC) cases and differences in the characteristics of CSC with and without steroids. A total of 538 eyes of 477 patients diagnosed with CSC, with 3 months or more of follow-up between April 2013 and June 2017 at 8 institutions. Patients with CSC with more than 3 months of follow-up were identified by OCT and fluorescein angiography at 8 institutions.
View Article and Find Full Text PDFOptical coherence tomography manifestations of primary vitreoretinal lymphoma.
Graefes Arch Clin Exp Ophthalmol
December 2016
Background: Primary vitreoretinal lymphoma (PVRL), a subset of primary central nervous system lymphoma (PCNSL), is a high-grade malignant tumor that shows various chorioretinal findings. Optical coherence tomography (OCT) is useful for detecting these lesions, and various abnormalities on OCT images have been reported. The purpose of this report was to investigate retrospectively the OCT manifestations of various disease stages and compare the manifestations of pretreatment, recurrent, and chronic cases.
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- Vogt-Koyanagi-Harada (VKH) disease and central serous chorioretinopathy (CSC) can both cause retinal detachment but require different treatments: steroids for VKH and avoidance for CSC.
- A 50-year-old patient initially diagnosed with VKH experienced blurry vision and was treated with steroids, leading to the resolution of some symptoms, but recurring serous macular detachment indicated an evolving condition.
- En face optical coherence tomography (OCT) imaging helped differentiate between VKH and emerging CSC, suggesting that secondary CSC can develop in VKH patients after steroid therapy.
Recently, a number of biologics have been used in the treatment of autoimmune diseases. However, in the treatment of severe autoimmune uveitis, only TNF-alpha inhibitors are preferably used and the effect of other biologics such as interleukin-6 (IL-6) signaling blockade or cytotoxic T-lymphocyte antigen-4-immunoglobulin fusion protein (CTLA4-Ig) has not been well studied. Previously, we reported that IL-6 blockade effectively suppresses the development of experimental autoimmune uveitis (EAU), a mouse model for uveitis, by inhibiting Th17 cell development.
View Article and Find Full Text PDFPurpose: Our aim was to determine the recurrence rate of inflammation in Vogt-Koyanagi-Harada (VKH) disease and to describe its clinical features.
Methods: We retrospectively evaluated patients diagnosed as having VKH disease with exudative retinal detachment at the Osaka University Hospital or the Japanese Community Healthcare Organization, Osaka Hospital, between 1998 and 2012. All patients received high-dose corticosteroid therapy as the initial treatment and were followed for at least 6 months.