Publications by authors named "Chiharu Asano"
Background: The significance of angiogenic factors as predictors of second-line (2L) chemotherapy efficacy when combined with angiogenesis inhibitors for metastatic colorectal cancer (mCRC) remains unestablished.
Patients And Methods: In this multicenter prospective observational study, 17 angiogenic factors were analyzed in plasma samples collected at pretreatment and progression stages using a Luminex multiplex assay. Patients who received chemotherapy plus bevacizumab (BEV group), FOLFIRI plus ramucirumab (RAM group), or FOLFIRI plus aflibercept (AFL group) as the 2L treatment were included.
Article Synopsis
- This study focused on identifying plasma angiogenesis factors that could help predict how well traditional chemotherapy combined with biologics works for patients with RAS wild-type metastatic colorectal cancer (mCRC).
- Researchers collected plasma samples before treatment and at the progression stage from 202 patients, analyzing 17 factors using specialized technology to assess their impact on patient survival.
- Results showed that levels of interleukin-8 and soluble vascular cell adhesion molecule-1 were linked to treatment effectiveness, indicating these could serve as important biomarkers for tailoring cancer therapies.
Wide hybridization, which is a powerful tool to broaden genetic variation, has been used in breeding of many crops. However, in ornamental gentian few wide hybridizations have been reported. Interspecific hybridizations between two gentian cultivated species ( and ) and 11 wild species, which were classified in five sections, were carried out using ovule culture.
View Article and Find Full Text PDFBackground: Pioglitazone is a thiazolidinedione drug that acts as an insulin sensitizer. We recently characterized DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome.
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