Publications by authors named "Chih-Wei Hsu"
Heterozygous pathogenic variants in are associated with oligodontia-colorectal cancer syndrome (ODCRCS), a disorder characterized by oligodontia, colorectal cancer, and in some cases, sparse hair and eyebrows. We have identified four individuals with one of two , heterozygous variants (NM_004655.4:c.
View Article and Find Full Text PDFDilated cardiomyopathy (DCM) is a highly prevalent and genetically heterogeneous condition that results in decreased contractility and impaired cardiac function. The FK506-binding protein FKBP12 has been implicated in regulating the ryanodine receptor in skeletal muscle, but its role in cardiac muscle remains unclear. To define the effect of FKBP12 in cardiac function, we generated conditional mouse models of FKBP12 deficiency.
View Article and Find Full Text PDFAudiovestibular Dysfunction Related to Anti-Phospholipid Syndrome: A Systematic Review.
Diagnostics (Basel)
November 2024
Article Synopsis
Importance: Viloxazine is a novel nonstimulant medication approved for the treatment of attention-deficit/hyperactivity disorder (ADHD).
Objectives: To investigate the whether viloxazine is associated with effective and acceptable outcomes when treating children and adolescents with ADHD and to evaluate these outcomes' associations with viloxazine doses and duration of treatment.
Data Sources: The MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, PsycINFO, and ClinicalTrial.
Article Synopsis
- The study researched the optimal dose of lurasidone for treating bipolar depression, focusing on efficacy, acceptability, and metabolic/endocrine effects.
- It reviewed five clinical trials involving 2,032 patients and found that doses between 40-60 mg significantly improved depression, anxiety, and quality of life while experiencing manageable side effects.
- Results indicated that while higher doses led to increased side effects and weight gain, a 40-60 mg dose was generally the best choice for treatment without major risks of dropout or manic switch.
Positive symptoms, negative symptoms, and emotional disturbances are core features of schizophrenia. Although horticultural therapy (HT) has shown promise as an adjunctive treatment, evidence supporting its effectiveness remains limited. This systematic review and meta-analysis aimed to assess the impact of HT on total symptoms, positive symptoms, negative symptoms, and emotional disturbances in individuals with schizophrenia.
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- An updated meta-analysis investigated the effects of intravenous iron supplementation on reducing red blood cell (RBC) transfusion risk in adult patients after cardiac surgery, incorporating recent data from 14 randomized controlled trials with a total of 2,043 subjects.
- Results revealed that intravenous iron significantly decreased the likelihood of RBC transfusions (relative risk 0.77) and improved postoperative hemoglobin levels and iron status compared to control groups.
- The findings suggest that integrating intravenous iron supplementation into perioperative care could enhance patient outcomes in blood management without increasing mortality risk.
Gene therapy with Adeno-Associated Viral (AAV) vectors requires knowledge of their tropism within the body. Here we analyze the tropism of ten naturally occurring AAV serotypes (AAV3B, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAVrh8, AAVrh10 and AAVrh74) following systemic delivery into male and female mice. A transgene expressing ZsGreen and Cre recombinase was used to identify transduction in a cell-dependent manner based on fluorescence.
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- This meta-analysis investigates how effective a single dose of intravenous steroids is for enhancing postoperative recovery quality in adult surgery patients, using validated QoR scales.
- The study included eleven randomized controlled trials with 951 patients and measured various outcomes, including overall recovery scores and pain management.
- Results show that intravenous steroids significantly improved recovery scores and reduced pain and nausea compared to placebo, suggesting they are beneficial for postoperative care.*
Article Synopsis
- - The study evaluated how well an AI chatbot (ChatPDF) could create abstracts from 30 academic psychiatric articles, comparing its output with that of human-written abstracts from 10 additional psychiatric papers.
- - The results showed low similarity and plagiarism rates in the AI-generated abstracts, but the quality varied: structured abstracts performed similarly to originals, while unstructured ones scored lower, and overall, inaccuracies were found in 30% of the AI conclusions.
- - Experts noted that while AI models like ChatPDF have potential for summarizing psychiatric information, caution is needed due to accuracy concerns in the final outputs.
Article Synopsis
- Psilocybin-assisted therapy has been shown to help reduce clinical depressive symptoms, but this study investigates how different types of psychological support influence its effectiveness.
- The research analyzed 10 clinical trials involving 515 patients with depression and categorized psychological support into four types, revealing a significant overall positive effect of psilocybin therapy.
- The findings indicate that while various psychological protocols were used, the type of support provided did not significantly impact the improvement of depressive symptoms in patients undergoing psilocybin therapy.
Objective: To evaluate the comparative effectiveness and acceptability of oral monotherapy using psychedelics and escitalopram in patients with depressive symptoms, considering the potential for overestimated effectiveness due to unsuccessful blinding.
Design: Systematic review and Bayesian network meta-analysis.
Data Sources: Medline, Cochrane Central Register of Controlled Trials, Embase, PsycINFO, ClinicalTrial.
The efficacy and acceptability of anti-inflammatory omega-3 polyunsaturated fatty acid supplements in sepsis management: a network meta-analysis of randomized controlled trials.
Prostaglandins Leukot Essent Fatty Acids
March 2024
Sepsis is a critical medical condition associated with high mortality for patients. Current pharmacological strategies for sepsis management or prevention had not achieved satisfactory results. The omega-3 fatty acids, with anti-inflammatory benefits, are considered to be promising agents for sepsis management/prevention.
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- Audiovestibular dysfunction in systemic lupus erythematosus (SLE) has been overlooked, affecting both hearing and balance systems, with various proposed mechanisms such as immune responses and medication side effects.
- Current tests for evaluating this dysfunction lack specificity and sensitivity, and there is no agreed-upon treatment strategy, though a specific steroid protocol has been suggested in the recent review of literature.
- The systematic review summarized existing research on the causes, examination methods, and potential treatments for audiovestibular issues in SLE, emphasizing the importance of timely recognition and management for possible reversibility of symptoms.
Study Objective: Although a prolonged heart rate-corrected QT interval (QTcI) is associated with an increased risk of mortality in the general population, its prognostic value in surgical patients remains unclear. We aimed to examine whether preoperative QTcI prolongation predicts short-term postoperative outcomes in elderly patients undergoing noncardiac surgery.
Design: The study was a retrospective analysis using the TriNetX network database.
Article Synopsis
- It included seven randomized controlled trials with a total of 622 patients, revealing that magnesium sulfate significantly improved overall recovery scores and specific aspects like pain and physical comfort compared to a placebo
- Additionally, magnesium sulfate also reduced the need for opioids during surgery and lowered instances of postoperative nausea and vomiting, indicating its potential benefits for pain management and patient recovery.
Cognitive impairment is a core symptom of schizophrenia. This study investigated the effects of mindful exercise on the cognitive performance of individuals with schizophrenia. A systematic review and meta-analysis were performed from inception to March 2023.
View Article and Find Full Text PDFThe efficacy and acceptability of various non-invasive brain stimulation (NIBS) interventions for autism spectrum disorder remain unclear. We carried out a systematic review for randomized controlled trials (RCTs) regarding NIBS for reducing autistic symptoms (INPLASY202370003). Sixteen articles (N = 709) met the inclusion criteria for network meta-analysis.
View Article and Find Full Text PDFBackground: Studies have demonstrated that exercise can mitigate the intensity of menstrual pain in primary dysmenorrhea, but the most effective type of exercise remains unclear. The objective of this systematic review and network meta-analysis was to evaluate the effectiveness of different exercise regimens in reducing pain associated with primary dysmenorrhoea.
Methods: Randomized controlled trials investigating the relationship between menstrual pain and exercise were selected from major electronic databases until February 2, 2024.
The prevalence of pediatric constipation ranges from 0.7 to 29.6% across different countries.
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- - This study evaluated how six factors (stimulation intensity, frequency, pulses per session, treatment duration, number of sessions, and total pulses) affect the effectiveness of rTMS in treating patients with treatment-resistant depression (TRD).
- - A meta-analysis of randomized controlled trials with 2,391 participants showed that all six parameters significantly influenced treatment efficacy, with pulses per session being the most predictive factor.
- - Higher stimulation frequency (over 10 Hz) and greater intensity were linked to improved treatment outcomes, suggesting that optimizing these parameters may enhance rTMS effectiveness for TRD patients.
Article Synopsis
- - Tissue clearing is crucial for viewing larger tissues or organs in 3D, and the text outlines a protocol that uses an aqueous-based method called EZ Clear on adult mouse tissues.
- - The protocol includes steps for proper perfusion and fixation of mouse organs, along with tips for effective lipid removal and matching the refractive index to improve imaging clarity.
- - It also offers imaging parameters to help visualize both external fluorescent dyes and natural fluorescent markers in the adult mouse tissues, directing readers to Hsu et al. for full protocol details.
Introduction: Despite its high lifetime prevalence rate and the elevated disability caused by posttraumatic stress disorder (PTSD), treatments exhibit modest efficacy. In consideration of the abnormal connectivity between the dorsolateral prefrontal cortex (DLPFC) and amygdala in PTSD, several randomized controlled trials (RCTs) addressing the efficacy of different noninvasive brain stimulation (NIBS) modalities for PTSD management have been undertaken. However, previous RCTs have reported inconsistent results.
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