Publications by authors named "Chih-Ping Chen"
Three indeno[1,2-b]quinoxaline-based passivators (CQs) with different functionalities including ketone, malononitrile, nitrile, and amine were prepared and used as passivators in perovskite solar cells (PSCs). All of them exhibit good thermal stability, low cost, and ease of preparation. The variation in molecular geometries, in planar and spiro-shaped designs with appropriate functional groups, highlights a comparison between their passivation properities.
View Article and Find Full Text PDFThe ternary blending strategy is a fundamental approach that is widely recognized in the field of organic optoelectronics. In our investigation, leveraging the inherent advantages of the ternary component blending methodology, we introduced an innovative design for organic photodetectors (OPDs) aimed at reducing the dark current density (J) under reverse bias. This pioneering effort involved combining two distinct conjugated molecules (IT-4F and IEICO-4F) with a conjugated polymer (PM7), resulting in a composite material characterized by a well-defined vertical phase separation.
View Article and Find Full Text PDFRapid confirmation of maternal origin of trisomy 21 by quantitative fluorescent polymerase chain reaction in a fetus associated with increased nuchal translucency, abnormal first-trimester maternal serum screening result and positive non-invasive prenatal testing for trisomy 21.
Taiwan J Obstet Gynecol
November 2024
Article Synopsis
- Prenatal diagnosis of mosaic trisomy 21 was successfully performed on a 41-year-old woman during an amniocentesis, revealing a mix of normal and abnormal cells in the fetus due to a Robertsonian translocation.
- Despite initial concerns, subsequent tests showed significant normalization in fetal cells, leading to a reassuring outcome.
- At 38 weeks, the mother delivered a healthy baby with normal development, confirming that even low-level chromosomal abnormalities can result in positive pregnancy outcomes.
Article Synopsis
- A 36-year-old woman underwent amniocentesis during her pregnancy due to her age, revealing mosaic trisomy 21 with varying levels of affected cells.
- Despite the genetic abnormality, she was advised to continue with the pregnancy and delivered a healthy baby at 37 weeks.
- Follow-up tests showed that the baby exhibited low-level mosaicism for trisomy 21 but was normal in phenotype and development at 2 months old.
Prenatal diagnosis of Jacobsen syndrome associated with a distal 11q deletion and a distal 8q duplication by chromosome microarray analysis in a fetus with a de novo unbalanced translocation of 46,XX,der(11)t(8;11)(q24.13;q23.3) and multiple congenital anomalies on fetal ultrasound.
Taiwan J Obstet Gynecol
November 2024
Article Synopsis
- The study discusses the prenatal diagnosis of Jacobsen syndrome in a 41-year-old pregnant woman, which was linked to specific chromosomal abnormalities detected through advanced genetic testing.
- The fetus exhibited multiple congenital anomalies including growth restrictions, heart defects, and physical deformities, prompting amniocentesis for further analysis.
- Chromosome microarray analysis (CMA) revealed significant deletions and duplications in chromosomes 11 and 8, respectively, confirming the diagnosis and illustrating the effectiveness of CMA in identifying complex genetic issues in prenatal cases.
Article Synopsis
- - A 30-year-old woman underwent prenatal ultrasound at 14 weeks and was found to be carrying a fetus with multiple congenital anomalies, prompting chromosome microarray analysis (CMA) after the pregnancy was terminated.
- - The analysis revealed a significant deletion on chromosome 5 (5q14.3-q31.1), affecting numerous genes, including NR2F1 and MEF2C, indicating a genetic basis for the fetal conditions observed.
- - CMA proves to be an effective tool in identifying genetic abnormalities in fetuses with unexplained congenital anomalies, highlighting its value in prenatal genetic testing.
Objective: We present prenatal diagnosis of a 14-Mb 11p11.2-p13 deletion by chromosome microarray analysis (CMA) in a pregnancy with fetal recombinant chromosome 11 syndrome of rec(11)del(11) (p11.2p13)ins(11) (q21p11.
View Article and Find Full Text PDFArticle Synopsis
- A case study discussed the use of expanded non-invasive prenatal testing (NIPT) to detect 1p36 deletion syndrome in a 37-year-old woman undergoing pregnancy via in vitro fertilization.* -
- The NIPT was positive for a genetic issue at 13 weeks, but tragically, the pregnancy ended with intrauterine fetal death after a follow-up amniocentesis, which confirmed chromosomal abnormalities.* -
- The findings highlight the efficacy of NIPT for early detection of genetic disorders, specifically familial unbalanced reciprocal translocation, which can aid in prenatal genetic counseling.*
Molecular cytogenetic analysis of mosaic 45,X/46,X,r(X) at amniocentesis in a fetus with hydrops fetalis.
Taiwan J Obstet Gynecol
September 2024
Detection of non-mosaic balanced homologous acrocentric rearrangement rea(21q21q) in a young woman with a history of pregnancy loss and a previous pregnancy with positive non-invasive prenatal testing for Down syndrome and rea(21q21q) Down syndrome in the fetus.
Taiwan J Obstet Gynecol
September 2024
Low-level mosaic trisomy 14 at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, positive non-invasive prenatal testing for trisomy 14, perinatal progressive decrease of the trisomy 14 cell line and a favorable fetal outcome.
Taiwan J Obstet Gynecol
September 2024
Article Synopsis
- A 37-year-old woman underwent amniocentesis due to her advanced maternal age and was found to have low-level mosaic trisomy 14 in her fetus, with varying percentages of trisomy cells in amniocyte analyses.
- Subsequent testing, including ultrasound and genetic counseling, showed no significant genomic imbalance, and the parents' karyotypes were normal.
- Ultimately, she delivered a healthy baby with no signs of trisomy 14, indicating that low-level mosaicism can lead to positive outcomes despite initial concerning test results.
Mosaic distal 13q duplication due to mosaic unbalanced translocation of 46,XY,der(14)t(13;14)(q32.2;p13)/46,XY at amniocentesis in a pregnancy associated with a favorable fetal outcome, perinatal progressive decrease of the aneuploid cell line and cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes.
Taiwan J Obstet Gynecol
September 2024
Article Synopsis
- A 37-year-old woman underwent amniocentesis during her pregnancy, revealing a mosaic unbalanced translocation with 46,XY,der(14)t(13;14)(q32.2;p13), indicating a duplication in the distal region of chromosome 13. !* -
- Despite the complex genetic findings and varying degrees of mosaicism (ranging from 30-56%), the pregnancy progressed normally and resulted in the delivery of a healthy baby. !* -
- Follow-up genetic tests at 4.5 months and 1 year showed continued mosaicism, but no adverse developmental outcomes were noted in the child, suggesting a favorable health prognosis. !*
Genetic counseling of mosaic and non-mosaic tetrasomy 9p at prenatal diagnosis.
Taiwan J Obstet Gynecol
September 2024
Article Synopsis
- - Genetic counseling for mosaic and non-mosaic tetrasomy 9p is complex due to potential congenital abnormalities and variations in genetic material across different tissues.
- - Challenges arise from both true-positive and false-positive results in non-invasive prenatal testing (NIPT), along with complications like uniparental disomy (UPD) and tissue-limited mosaicism.
- - This article offers a thorough review of the counseling issues related to prenatal diagnosis of tetrasomy 9p, making it a valuable resource for genetic counselors.
Article Synopsis
- * Mosaic deletion can lead to varying outcomes; some cases show normal development while others present with abnormalities, creating challenges in prenatal diagnosis.
- * It discusses important counseling topics like culture artifacts, discrepancies in cytogenetic results, the potential for a decrease in the abnormal cell line over time, and the possibility of a favorable outcome for the fetus, which can aid healthcare professionals in advising parents.
Article Synopsis
- * It reviews documented instances of this type of mosaicism and the associated counseling complexities, including issues such as culture artifacts and discrepancies between different cell types.
- * The article emphasizes the importance of providing relevant information for obstetricians and genetic counselors to help parents make informed decisions regarding pregnancies affected by these genetic conditions.
Genetic counseling of mosaicism for balanced or unbalanced translocation with a normal cell line at amniocentesis.
Taiwan J Obstet Gynecol
September 2024
Article Synopsis
- Genetic counseling for mosaicism with balanced translocation at amniocentesis is generally straightforward due to most cases presenting normal phenotypes.
- In contrast, counseling for mosaicism with unbalanced translocation is complex, as outcomes can vary, resulting in either normal or abnormal phenotypes.
- The article reviews reported cases of mosaic unbalanced translocation, addressing various genetic factors and challenges for genetic counselors and obstetricians aiding parents considering the outcomes.
Herein, we present a series of stable radicals containing a trityl carbon-centered radical moiety exhibiting interesting properties. The radicals demonstrate the most blue-shifted anti-Kasha doublet emission reported so far with high color purity (full width at half-maximum of 46 nm) and relatively high photoluminescence quantum yields of deoxygenated toluene solutions reaching 31%. The stable radicals demonstrate equilibrated bipolar charge transport with charge mobility values reaching 10 cm/V·s at high electric fields.
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