Publications by authors named "Chih-Ken Chu"
We demonstrate effective inactivation of oral cancer cells SAS through a combination of photothermal therapy (PTT) and photodynamic therapy (PDT) effects based on localized surface plasmon resonance (LSPR) around 1064 nm in wavelength of a Au nanoring (NRI) under femtosecond (fs) laser illumination. The PTT effect is caused by the LSPR-enhanced absorption of the Au NRI. The PDT effect is generated by linking the Au NRI with the photosensitizer of sulfonated aluminum phthalocyanines (AlPcS) for producing singlet oxygen through the LSPR-enhanced two-photon absorption (TPA) excitation of AlPcS.
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- - The study investigates the use of gold nanorings (Au NRIs) with localized surface plasmon resonance (LSPR) to inactivate SAS oral cancer cells using a specific laser wavelength (1065 nm) to induce a photothermal effect.
- - Different incubation times are analyzed to measure how effectively the cancer cells absorb Au NRIs, with findings showing that internalization increases over time, particularly with antibody-linked Au NRIs, while the number of Au NRIs on the cell surface peaks at 12 hours.
- - Results indicate that Au NRIs on the cell membrane are more effective in killing cancer cells compared to those that are internalized, highlighting the significance of both incubation time and the presence of antibodies in optimizing cancer cell in