Automatic Single-Cell Harvesting for Fetal Nucleated Red Blood Cell Isolation on a Self-Assemble Cell Array (SACA) Chip.

(1) Background: Fetal chromosomal examination is a critical component of modern prenatal testing. Traditionally, maternal serum biomarkers such as free β-human chorionic gonadotropin (Free β-HCG) and pregnancy-associated plasma protein A (PAPPA) have been employed for screening, achieving a detection rate of approximately 90% for fetuses with Down syndrome, albeit with a false positive rate of 5%. While amniocentesis remains the gold standard for the prenatal diagnosis of chromosomal abnormalities, including Down syndrome and Edwards syndrome, its invasive nature carries a significant risk of complications, such as infection, preterm labor, or miscarriage, occurring at a rate of 7 per 1000 procedures.

Spontaneous autoinflation and deflation of double-lumen breast implants.

A rare late complication of textured, double-lumen breast implants developed 15 years after routine augmentation mammaplasty. The patient required secondary surgery for removal of the implants in both breasts because of their spontaneous autoinflation and deflation. Mammography showed autoexpansion of the right breast implant and deflation of left breast implant in the outer lumen without evidence of silicone leakage 15 years after implantation.