Neural correlates of memory deficits in premanifest -repeat expansions.

Background: The premanifest stage in carriers of hexanucleotide repeat expansions in the gene (C9RE) is associated with memory impairment. The present study examines whether the impairment is general across domains or disproportionately affects specific stimulus categories such as socioemotional events, and its underlying functional neuroanatomy.

Methods: This task-based fMRI-study included 21 premanifest C9RE (preC9RE) carriers and 24 controls.