Publications by authors named "Chih-Feng Yen"

Article Synopsis
  • Dienogest is an effective long-term treatment for pelvic pain caused by endometriosis, but Taiwan lacks a tailored consensus on its use.
  • Taiwanese experts, in collaboration with the Taiwan Endometriosis Society, developed structured recommendations for administering and monitoring dienogest.
  • They recommend ongoing treatment for symptom control, regular ultrasounds and blood tests for monitoring, and additional breast screenings for high-risk patients to enhance safety and treatment outcomes.
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Objective: To study the effect of adenomyosis on the localized expression of the GATA binding proteins 2 and 6 (GATA2 and GATA6) zinc-finger transcription factors that are involved in proliferation of hematopoietic and endocrine cell lineages, cell differentiation, and organogenesis, potentially leading to impaired endometrial implantation.

Design: Laboratory based experimental study.

Setting: Academic hospital and laboratory.

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Endometriosis should be diagnosed as early as possible in the continuum of care; but substantial delays of approximately 6-8 years between symptom onset and endometriosis diagnosis have been widely reported. With the purpose of improving the prompt diagnosis of endometriosis, the Asia-Pacific Endometriosis Expert Panel (APEX) sought to address the reasons for diagnostic delays across the region, and formulate a multi-pronged approach to overcoming these challenges. In the first instance, clinical diagnosis is preferable to surgical diagnosis, in order to facilitate earlier empirical treatment and minimize the negative sequelae of undiagnosed/untreated disease.

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Objective: Laparoscopic box simulation training is widely recognized as an assessment tool to facilitate psychomotor skills especially for novice surgeons. However, current commercialized training modules including pegs, gauze, clips, pins etc. are generally costly and relatively inaccessible.

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This work provides consensus guidance regarding clinical diagnosis and early medical management of endometriosis within Asia. Clinicians with expertise in endometriosis critically evaluated available evidence on clinical diagnosis and early medical management and their applicability to current clinical practices. Clinical diagnosis should focus on symptom recognition, which can be presumed to be endometriosis without laparoscopic confirmation.

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Objective: To assess the technical feasibility of laparoscopic tubocornual anastomosis (TCA) at restoring tubal patency in patients with proximal tubal occlusions.

Materials And Methods: A retrospective analysis of fourteen females with identified proximal tubal occlusions seeking to restore their tubal patency in a university-affiliated tertiary hospital between 2011 and 2018. Tubal patency within one year after the surgery was evaluated.

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Study Objective: Although a pericervical tourniquet helped reduce blood loss in myomectomy [1], a technique of triple tourniquets was more influential in occluding the uterine vessel networks [2,3]. This video demonstrates the procedures of laparoscopic triple-tourniquet constriction with the number 1 suture around the uterine isthmic portion and bilateral infundibulopelvic ligaments [4] in a case of robotic myomectomy.

Design: A step-by-step, narrated video demonstration.

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Interpenetrating porous coordination polymers (IPCPs) consist of two or more networks that are mechanically interlocked to form a coherent structure. The framework topology and the chemical composition are the two important criteria of interpenetrating networks to distinguish homo-IPCPs from hetero-IPCPs. Compared to rich homo-IPCPs, hetero-IPCPs remain rare and are formed rather unexpectedly.

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Article Synopsis
  • This study investigates the feasibility of using vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) to treat early-stage endometrial cancer through various surgical procedures including hysterectomy and lymph node biopsy.
  • A total of 15 patients aged 20 to 80 were examined, with an average age of about 53 years; the surgeries had a mean duration of 231.4 minutes and an average blood loss of 122 mL, showing generally minimal complications.
  • The findings suggest that vNOTES is a practical method for surgical staging in early-stage endometrial cancer, but further research with a larger group is needed to confirm the long-term effectiveness and safety of this
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Objective: To demonstrate the implementation and potential benefits of hysteroscopic removal, with or without concomitant laparoscopic assistance, of first-trimester cesarean scar pregnancies (CSPs).

Design: Patients with prior cesarean deliveries may have scar formation at the muscular wall of the uterine isthmus, resulting in a cesarean scar defect (CSD), also known as an isthmocele or diverticulum. When implantation of a trophoblast occurs at the CSD, a CSP develops, and with progression onto higher gestational age, it carries risks for serious complications, such as placenta previa spectrum, life-threatening bleeding, uterine rupture, and cesarean hysterectomy.

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Endometrial cancer incidence increases annually. Several risk factors, including high glucose intake, are associated with endometrial cancer. We investigated whether glucose affects lysine-specific demethylase 1 (LSD1) expression and the responsible molecular mechanisms.

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Estrogens can elicit rapid cellular responses via the G-protein-coupled receptor 30 (GPR30), followed by estrogen receptor α (ERα/ESR1)-mediated genomic effects. Here, we investigated whether rapid estrogen signaling via GRP30 may affect ESR1 expression, and we examined the underlying molecular mechanisms. The exposure of human endometrial cancer cells to 17β-estradiol promoted p62 phosphorylation and increased ESR1 protein expression.

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Interval Laparoscopic Transabdominal Cervical Cerclage (ILTACC) has become a procedure of choice for many laparoscopic surgeons in nonpregnant patients diagnosed with cervical incompetence (CI) due to the inherent advantages it offers. The study was conducted to describe the feasibility of performing a three-step approach of ILTACC using a needleless mersilene tape in patients diagnosed with CI. A case series of three patients diagnosed with CI who underwent ILTACC using needleless mersilene tape referred at a tertiary hospital for cerclage.

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Objective: To demonstrate an innovative idea for a four-petal method for performing laparoscopic adenomyomectomy on a patient with focal-type adenomyosis.

Design: A step-by-step explanation of the technique with narrated video footage.

Setting: University hospital.

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Objective: To demonstrate laparoscopic surgery for a patient with unicornuate uterus and a large hematometra in the noncommunicating uterine horn.

Design: Narrated video featuring the diagnostic tests and surgical management.

Setting: Academic tertiary hospital.

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Aim: With a perplexing pathogenesis and an incidence rate of approximately 10% among women of reproductive age, endometriosis affects more women in Asia than in any other continent in the world. This paper reviews the available data on the epidemiology and risk factors associated with endometriosis in East Asia.

Methods: Included studies were published between January 2000 and December 2016.

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