Melanocyte transplantation to skin prepared by controlled PUVA-induced sunburn-like blistering for vitiligo treatment - A pilot clinical trial.

Vitiligo is a common acquired disease of pigment loss. In lesions recalcitrant to non-invasive treatment, transplantation of cultured autologous melanocytes is an emerging choice. Conventionally, the recipient site is often prepared by laser-mediated or mechanical dermabrasion.

Safety and efficacy of intracoronary artery administration of human bone marrow-derived mesenchymal stem cells in STEMI of Lee-Sung pigs-A preclinical study for supporting the feasibility of the OmniMSC-AMI phase I clinical trial.

Background: This study tested whether early left intracoronary arterial (LAD) administration of human bone marrow-derived mesenchymal stem cells (hBMMSCs, called OmniMSCs) in acute ST-segment elevation myocardial infarction (STEMI) of Lee-Sung pigs induced by 90 min balloon-occluded LAD was safe and effective.

Methods And Results: Young male Lee-Sung pigs were categorized into SC (sham-operated control,  = 3), AMI-B (STEMI + buffer/21 cc/administered at 90 min after STEMI,  = 6), and AMI-M [acute myocardial infarction (AMI) + hBMMSCs/1.5 × 10/administered at 90 min after STEMI,  = 6] groups.

Orthodontic force regulates metalloproteinase-3 promoter in osteoblasts and transgenic mouse models.

Background/purpose: Previously we demonstrated up-regulation of matrix metalloproteinase-3 () in human osteoblasts under compression and in bony specimens of experimental orthodontic tooth movement (OTM). Here, we studied the temporal characteristics of compression stimulation in human and mouse osteoblast cell lines, and generated a transgenic mouse model for assessing the expression during OTM.

Materials And Methods: We investigated expressions in human and murine osteoblasts through RT-PCR and luciferase assay, after compressive force loading.