Publications by authors named "Chih Hung Lai"
Automated analysis of flow cytometry data can improve objectivity and reduce analysis time but has generally required work by software and algorithm experts. Here, we investigated the performance of BD ElastiGate™ Software (hereafter ElastiGate), which allows users to automate gating by selecting gated training files, then uses elastic image registration to gate new files. Three assays of increasing complexity were examined: TBNK, stem cell enumeration (SCE), and lymphoid screening tube (LST).
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- Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A gene, leading to harmful buildup of glycosphingolipids in various tissues and classified into classic and late-onset phenotypes.
- Classic phenotype shows severely reduced enzyme activity, resulting in a progressive disease with multi-organ issues, while late-onset often presents with milder symptoms and mainly affects the heart due to some remaining enzyme activity.
- Early diagnosis through enzyme testing, imaging, and genotyping is crucial for effective treatment, which includes enzyme replacement therapy and new pharmacological options to prevent irreversible damage and optimize patient care based on genetic and gender considerations.
Background: It is crucial to identify factors that can predict the risk of mortality in patients newly diagnosed with interstitial lung disease (ILD). This study sought to develop and assess a composite scoring system for mortality prediction among ILD patients based on cardiovascular parameters, which were previously reported as predictors of survival.
Methods: We prospectively enrolled patients with newly diagnosed ILD and monitored their survival status for 24 months.
Background: Human leukocyte antigen () genes are important in many immune processes and contribute to many adverse drug reactions. Whether genetic variations in the region are associated with non-steroid anti-inflammatory drug (NSAID) hypersensitivity remains uncertain. Therefore, the aim of our study was to identify genetic variations in patients with NSAID hypersensitivity in the Taiwanese population.
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- A nationwide registry study is being conducted in Taiwan with 3,600 patients to better understand the treatment of acute coronary syndrome (ACS) by gathering data during and after hospitalization.
- Data will be collected at three key time points: during hospitalization, 6 months, and 12 months post-discharge to assess the use of guideline-directed therapies and identify predictors of one-year health outcomes.
- The study aims to improve ACS treatment by analyzing results over the next 20 years, enhancing knowledge about the adherence to medical guidelines and patient prognoses.
Background: We aimed to evaluate the efficacy and safety of the 'jailed semi-inflated balloon technique' (JSIBT) for side branch (SB) protection in STEMI patients with a culprit lesion involving a coronary artery bifurcation while undergoing emergent percutaneous coronary intervention (PCI).
Methods: We treated between Jan, 2011 and Jun, 2020, a total of 264 STEMI patients with a culprit lesion that involved a coronary artery bifurcation using primary PCI. In 30 patients, SB was protected by JSIBT (the JSIBT group).
Background: There are limited reports on the treatment of complex calcified lesions using rotational atherectomy (RA) in octogenarians, particularly in high-risk patients.
Objective: To evaluate procedural and clinical outcomes of RA in octogenarians.
Methods: Consecutive RA patients from 2010 to 2018 were selected from our catheterization laboratory database, stratified into two groups (≥ or < 80 years old), and analyzed.
Article Synopsis
- Hypertension is influenced by genetic and environmental factors, with LEENE (a lncRNA) previously shown to enhance nitric oxide production and blood vessel growth, but its role in blood pressure regulation remains unclear.
- In experiments on mice, those lacking LEENE showed significantly higher blood pressure and increased heart and kidney damage when exposed to Angiotensin II, suggesting LEENE plays a protective role.
- The study indicates that boosting LEENE levels can help restore normal signaling in endothelial cells, pointing to its potential as a regulator of blood pressure control.
Background: Despite advances being made in techniques and devices, certain chronic total occlusion (CTO) lesions remain uncrossable or undilatable. Rotational atherectomy (RA) is usually necessary for such lesions to achieve successful revascularization.
Methods: Information regarding consecutive patients who underwent coronary RA was retrieved from the catheterization laboratory database.
Background And Purpose: Targeted temperature management (TTM) has been recommended for post-resuscitation care of cardiac arrest (CA) patients who remain comatose. However, the differences between cardiogenic and non-cardiogenic causes need further investigation. Thus, this study aimed to investigate the difference in outcomes between cardiogenic and non-cardiogenic CA patients receiving TTM.
View Article and Find Full Text PDFBackground: Post-resuscitation hemodynamic level is associated with outcomes. This study was conducted to investigate if post-resuscitation diastolic blood pressure (DBP) is a favorable prognostic factor.
Methods: Using TaIwan Network of Targeted Temperature ManagEment for CARDiac Arrest (TIMECARD) registry, we recruited adult patients who received targeted temperature management in nine medical centers between January 2014 and September 2019.
Background And Purpose: Targeted temperature management (TTM) is associated with decreased mortality and improved neurological function after cardiac arrest. Additionally, studies have shown that bystander cardiopulmonary resuscitation (BCPR) doubled the survival of patients with out-of-hospital cardiac arrest (OHCA) compared to patients who received no BPCR (no-BCPR). However, the outcome benefits of BCPR on patients who received TTM are not fully understood.
View Article and Find Full Text PDFBackground: Rotational atherectomy (RA) is an indispensable tool used for calcified lesion preparation in percutaneous coronary intervention (PCI). However, use of RA in the setting of acute myocardial infarction (AMI) is challenged with limited clinical data.
Objectives: This study aims to retrospectively investigate the procedural results, periprocedural complications, and clinical outcomes of RA in patients with AMI.
Objective: Patients with advanced renal insufficiency are at high risk of coronary artery disease (CAD) and complex lesions. Treating complex calcified lesion with rotational atherectomy (RA) in these patients might be associated with higher risks and poorer outcomes. This study was set to evaluate features and outcomes of RA in these patients.
View Article and Find Full Text PDFSub-optimal sensitivity and specificity in current allograft monitoring methodologies underscore the need for more accurate and reflexive immunosurveillance to uncover the flux in alloimmunity between allograft health and the onset and progression of rejection. QSant-a urine based multi-analyte diagnostic test-was developed to profile renal transplant health and prognosticate injury, risk of evolution, and resolution of acute rejection. Q-Score-the composite score, across measurements of DNA, protein and metabolic biomarkers in the QSant assay-enables this risk prognostication.
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- - Fabry disease (FD) is a rare genetic disorder caused by mutations in the α-galactosidase A gene, leading to a lack of the enzyme and the harmful buildup of certain lipids (globotriaosylceramide) in various organs, potentially causing inflammation.
- - The disease can manifest either as a classic form with early onset affecting multiple systems (skin, nerves, kidneys, heart) or as a later-onset cardiac variant, characterized by severe heart issues, including hypertrophy and arrhythmias, which can increase the risk of sudden cardiac death.
- - Advances in diagnostic tools like cardiac MRI and echocardiography help in assessing heart involvement in FD, and early detection through teamwork among
BACKGROUND This study aimed to compare outcomes of targeted temperature management (TTM) for patients with in-hospital and out-of-hospital cardiac arrest using the national database of TaIwan network of targeted temperature ManagEment for CARDiac arrest (TIMECARD) registry. MATERIAL AND METHODS A retrospective, matched, case-control study was conducted. Patients with in-hospital cardiac arrest (IHCA) treated with TTM after the return of spontaneous circulation (ROSC) were selected as the case group and controls were defined as the same number of patients with out-of-hospital cardiac arrest (OHCA), matched for sex, age, Charlson comorbidity index, and cerebral performance category.
View Article and Find Full Text PDFIntroduction: Uniportal video-assisted thoracoscopic surgery (VATS) for various pulmonary diseases provides advantages of less postoperative pain and earlier post-operative recovery over traditional open surgery. The inherent limitation of this surgical modality in manipulation of surgical instruments renders intra-operative one-lung ventilation a requisite to increase the substantially restricted working space and thus visibility of the surgical filed.
Patient Concerns: Patient 1, an 8-month-old, 9-kg, and 70 cm-in-height male infant was diagnosed as congenital pulmonary airway malformation (CPAM) over left lower lobe.
Article Synopsis
- * Researchers analyzed data from 540 patients and found that the mortality rate was 58.1%, with only 21.7% achieving favorable neurologic outcomes at hospital discharge.
- * Key factors affecting these outcomes included initial shockable heart rhythms, witnessed cardiac arrest, bystander CPR, and certain health conditions like diabetes and chronic kidney disease, highlighting the importance of both pre- and post-arrest factors.
The homeostasis of vascular endothelium is crucial for cardiovascular health and endothelial cell (EC) aging and dysfunction could negatively impact vascular function. Leveraging transcriptome profiles from ECs subjected to various stimuli, including time-series data obtained from ECs under physiological pulsatile flow vs. pathophysiological oscillatory flow, we performed principal component analysis (PCA) to identify key genes contributing to divergent transcriptional states of ECs.
View Article and Find Full Text PDFThe treatment of patients with multivessel coronary artery disease (MVD) by coronary stenting (PCI) and the "gold standard" conventional coronary-artery bypass grafting (C-CABG) has been well explored in the literature. However, the clinical outcomes of robot-assisted CABG (R-CABG) vs C-CABG in MVD patients in real-world practice were unknown. We aimed to study the clinical outcomes of MVD patients who underwent R-CABG (robotic MIDCAB) and C-CABG at our institution between January 2005 and December 2013.
View Article and Find Full Text PDFObjective: Heavy calcifications remain formidable challenges to PCI, even for well-experienced operators. However, rotational atherectomy (RA)-induced coronary perforations (CPs) still could not be obviated. This study was to explore incidence and mechanisms of RA-induced CP in real-world practice.
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- - Post-cardiac arrest care is essential for recovery, but integrating recent scientific findings into clinical practice presents challenges due to the complexity of care required across multiple disciplines.
- - A consensus scientific statement was created with input from experts in various fields related to post-cardiac arrest care, supported by major emergency and critical care organizations.
- - Key recommendations include using targeted temperature management, assessing for acute coronary events, and ensuring intensive hemodynamic and respiratory care to improve patient outcomes after cardiac arrest.