[The CNS lesion in monkeys spinally infected with the vaccinal poliomyelitis virus].

Specific features of the CNS lesions in monkeys inoculated with a vaccine poliovirus strain were studied in comparison with those developing after inoculation with virulent strains. The lesions in the lumbar cord and other regions of the brain and spinal cord after intraspinal inoculation of the vaccine virus are described at length. Certain signs reflecting the specific nature of the lesions were observed.

[Comparative pathomorphologic study of the toxic properties of a corpuscular pertussis vaccine and of a cell-free pertussis preparation].

The comparative study of morphological changes in the body of outbred mice under the action of corpuscular pertussis vaccine and acellular pertussis preparation has been made. The corpuscular vaccine has been shown to produce a pronounced, dynamically increasing toxic effect, thus causing the damage of lymphoid thymic and spleen cells, prolonged interstitial reaction in the lungs, destructive inflammatory process at the site of injection. The acellular pertussis preparation is less toxic, induces less pronounced changes in these organs at the early period of the experiment, stimulates the proliferation of lymphoid cells and lymphoblast transformation.

[Comparative assessment of the neurovirulence of vaccinal strains of the rabies virus].

Neurovirulence of three vaccine strains of rabies virus ("Moscow", "Vnukovo-32", and "MIVP-74") was studied in mice using pathomorphology data. After intracerebral inoculations changes in the CNS were similar. The presence and the degree of the involvement of the Ammon horn is the main indicator of the infectious activity of the strain.

[Pathogenesis of an infection induced in Syrian hamsters by attenuated strains of viruses of the tick-borne encephalitis complex].

The results of virological and morphological study of the pathogenesis of the infection induced by viruses of the tick-borne encephalitis complex (attenuated TP-21 and E-30 strains) in Syrian hamsters with normal and suppressed immune response are presented. The data obtained indicate long-term persistence of the virus-specific antigen: sufficiently high titres of specific antibodies in the blood serum of the animals at late periods after virus inoculation, positive immunoenzyme tests for virus antigen in the meninges of the hamsters inoculated with the TP-21 strain. Features of the pathogenesis were found to be related to strain characteristics, particularly the degree of their attenuation.

[Morphological study of neurovirulence of the Vnukovo-32 strains of rabies virus].

The central nervous system of white mice inoculated with the production Vnukovo-32 strain of tissue culture rabies virus was studied histologically. Intracerebral inoculation resulted in parenchymatous-inflammatory lesions with predominantly severe involvement of the Ammon horn neurons. Subcutaneous inoculations also revealed a rather significant degree of neurovirulence of this strain, although there were definite differences in the pathomorphological pictures observed after inoculation by this and intracerebral route.