Publications by authors named "Chiffvon P Stanley"
Developmental transitions in electrical activation patterns in chick embryonic heart.
Anat Rec A Discov Mol Cell Evol Biol
October 2004
The specialized conduction tissue network mediates coordinated propagation of electrical activity through the adult vertebrate heart. Following activation of the atria, the activation wave is slowed down in the atrioventricular canal or node, then spreads rapidly into the left and right ventricles via the His-Purkinje system (HPS). This results in the ventricle being activated from the apex toward the base and is thought to represent HPS function.
View Article and Find Full Text PDFWe review here the evolution and development of the earliest components of the cardiac pacemaking and conduction system (PCS) and the turnover or persistence of such cells into old age in the adult vertebrate heart. Heart rate is paced by upstream foci of cardiac muscle near the future sinoatrial junction even before contraction begins. As the tubular heart loops, directional blood flow is maintained through coordinated sphincter function in the forming atrioventricular (AV) canal and outflow segments.
View Article and Find Full Text PDFArticle Synopsis
- The His-Purkinje system (HPS) is crucial for coordinating the contraction of the heart's ventricles, with its development showing a shift from base-to-apex activation to a more mature apex-to-base sequence.
- Studies using imaging techniques in chick embryos suggest that changes in heart hemodynamics significantly impact the timing of this maturation process, with increased hemodynamic load accelerating development and reduced load delaying it.
- This research highlights the importance of mechanical factors in cardiac development and sets the stage for further investigation into the molecular mechanisms that guide the formation and organization of the HPS.