Publications by authors named "Chier Du"
Article Synopsis
- - Atherosclerotic plaques lead to serious heart diseases, driven by oxidative stress, lipid issues, and ongoing inflammation, but current drugs only target individual problems rather than the whole issue.
- - Researchers developed a new treatment called Lip@HS, which combines a gas therapy with a specialized nanozyme that specifically targets harmful cells in atherosclerotic plaques.
- - This new approach uses ultrasound to activate the nanozyme, enhancing lipid metabolism and reducing inflammation, showing promise as a comprehensive treatment for atherosclerosis.
Metastasis and recurrence are notable contributors to mortality associated with breast cancer. Although immunotherapy has shown promise in mitigating these risks after conventional treatments, its effectiveness remains constrained by significant challenges, such as impaired antigen presentation by dendritic cells (DCs) and inadequate T cell infiltration into tumor tissues. To address these limitations, we developed a multifunctional nanoparticle platform, termed GM@P, which consisted of a hydrophobic shell encapsulating the photosensitizer MHI148 and a hydrophilic core containing the STING agonist 2'3'-cGAMP.
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- * The nanoparticles are designed to deliver the chemotherapy drug doxorubicin (DOX) and NO donor L-arginine (L-Arg) while being tracked in real-time using advanced imaging techniques like magnetic resonance and photoacoustic imaging.
- * The approach enhances vascular integrity, promotes the breakdown of collagen around tumors, and combines the effects of DOX and heat from manganese ferrite (MnFeO) to create a synergistic treatment for TNBC.
Background: The prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although metalloimmunotherapy has shown potential in combating tumor proliferation, recurrence and metastasis, current apoptosis-based metalloimmunotherapy fails to elicit sufficient immune response for HCC.
Results: A smart responsive bimetallic nanovaccine was constructed to induce immunogenic cell death (ICD) through pyroptosis and enhance the efficacy of the cGAS-STING pathway.
Activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway has emerged as an efficient strategy to improve the therapeutic outcomes of immunotherapy. However, the "constantly active" mode of current STING agonist delivery strategies typically leads to off-target toxicity and hyperimmunity. To address this critical issue, herein a metal-organic frameworks-based nanoagonist (DZ@A7) featuring tumor-specific and near-infrared (NIR) light-enhanced decomposition is constructed for precisely localized STING activation and photodynamic-metalloimmunotherapy.
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- Excessive reactive oxygen species (ROS), metal ion buildup, and dysfunction in the tricarboxylic acid cycle are key factors leading to cell death in mitochondria, which poses challenges for cancer treatment.
- A new self-reinforced bimetallic Mito-Jammer combines doxorubicin and calcium peroxide with metal-organic frameworks to target tumors more effectively by generating ROS in the tumor environment.
- This innovative approach not only amplifies mitochondrial damage and reduces ATP levels to enhance tumor cell death but also promotes immune responses and inhibits tumor spreading.
Multidrug resistance (MDR) and metastasis in cancer have become increasingly serious problems since antitumor efficiency is greatly restricted by a single therapeutic modality and the insensitive tumor microenvironment (TME). Herein, metal-phenolic network-functionalized nanoparticles (t-P@TFP NPs) are designed to realize multiple therapeutic modalities and reshape the TME from insensitive to sensitive under multimodal imaging monitoring. After a single irradiation, a near-infrared laser-activated multistage reaction occurs.
View Article and Find Full Text PDFCancer multidrug resistance (MDR) is an important reason that results in chemotherapy failure. As a main mechanism of MDR, overexpressed P-glycoprotein (P-gp) utilizes adenosine triphosphate (ATP) to actively pump chemotherapy drugs out of cells. In addition, metabolic reprogramming of drug-resistant tumor cells (DRTCs) exacerbates the specific hypoxic microenvironment and promotes tumor metastasis and recurrence.
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