In-vitro characterization and evaluation of mesoporous titanium dioxide composite hydroxyapatite and its effectiveness in occluding dentine tubules.

Background: To synthesize mesoporous titanium dioxide composite hydroxyapatite (TiO-HAP) and to evaluate its effectiveness in sealing of occluding dentine tubules.

Methods: TiO-HAP was synthesized by chemical precipitation method and characterized using infrared absorption spectrometer, X-ray diffraction, scanning electron microscope, and specific surface area detector. Forty completely extracted molars were prepared and randomly assigned into Control group, Gluma group, HAP group and TiO-HAP group according to different treatments.

Synthesis of novel lipophilic N-substituted norcantharimide derivatives and evaluation of their anticancer activities.

This research attempted to study the effect of lipophilicity on the anticancer activity of N-substituted norcantharimide derivatives. Twenty-three compounds were synthesized and their cytotoxicities against five human cancer cell lines studied. The lipophilicity of each derivative was altered by its substituent, an alkyl, alkyloxy, terpenyl or terpenyloxy group at the N-position of norcantharimide.