Publications by authors named "Chien-Ying Ho"
On minimal focal distance of a focused ultrasound probe for neuromodulation.
JASA Express Lett
February 2023
Focal distance is a key parameter for a focused ultrasound probe, especially in mouse brain stimulation where targets are right below the skull. A closed-form solution for the minimal focal distance with a given transducer size was derived in this study to facilitate precise focal spot alignment with targets in the mouse brain. The spherical profile corresponding to the minimal focal distance does not produce accurate focusing.
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- Delivering drugs to the inner ear is difficult because of a barrier called the blood-labyrinth barrier.
- A method called intracochaear drug delivery, though invasive, reduces variability in how the drug is processed by the body.
- This study found that using low-intensity ultrasound increased the uptake of the drug cisplatin in hair cells from cochlear explants of newborn mice, with uptake starting from the outer part of the hair cells and moving inward over time.