Publications by authors named "Chien-Hui Chan"
Article Synopsis
- Sotorasib is the first FDA-approved KRAS inhibitor for treating KRAS-mutant non-small-cell lung cancer, but cancer cells can develop resistance to it over time.
- Researchers discovered that sotorasib-resistant cancer cells are dependent on the inhibitor for survival, prompting an investigation into the underlying mechanisms of this addiction.
- The study found that without sotorasib, resistant cells experience stress and DNA damage, leading to cell cycle arrest and apoptosis, and that activating the MAPK pathway can enhance the effects of sotorasib withdrawal both in laboratory and animal models.
Article Synopsis
- KRAS is a common oncogene mutation in cancer, and while covalent inhibitors like sotorasib show promise, resistance can limit their effectiveness.
- Researchers established sotorasib-resistant cell lines and found that these cells activate certain signaling pathways that contribute to this resistance, including increased cell adhesion and the activation of p21-activated kinases (PAKs) and the PI3K/AKT pathway.
- Inhibiting PAK with compounds like FRAX597 and using the PI3K inhibitor alpelisib in combination with sotorasib significantly reduced the viability of KRAS mutant cancer cells, highlighting a mutual regulatory loop that contributes to resistance.
Systemic capillary leak syndrome (SCLS) is a syndrome caused by many reasons and without a definitive mechanism. The main diagnostic criteria of SCLS are hemoconcentration, hypoalbuminemia, and hypotension. Though most SCLS improved spontaneously within a few days, it can be life-threatening without effective treatments.
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- * Researchers developed a new prognostic model called HANBAH, which identifies key factors (hemoglobin level, age, sodium level, blood urea nitrogen level, atrial fibrillation, and high-density lipoprotein level) to predict patient mortality more accurately.
- * The HANBAH scoring system has shown to be more effective than previous models in predicting both short- and long-term mortality, confirmed by both traditional statistical methods and modern machine learning techniques.
Article Synopsis
- The study aimed to assess how effective transvaginal aspiration with ethanol sclerotherapy is for treating cysts in patients who had prior endometriosis surgery, using data mining to identify success factors.
- Conducted at a teaching hospital in Taiwan, the retrospective cohort study included 196 patients and involved 274 procedures, with follow-ups at 3, 6, and 12 months to monitor complications, cyst size, and pain levels.
- Results showed a significant reduction in cyst size and pain, with 17.8% of previously infertile patients achieving pregnancy, and longer treatment times correlated with higher recovery rates.
Interleukin-20 (IL-20) is a proinflammatory cytokine involved in rheumatoid arthritis, atherosclerosis, and osteoporosis. However, little is known about the role of IL-20 in oral cancer. We explored the function of IL-20 in the tumor progression of oral cancer.
View Article and Find Full Text PDFIL-20 is a proinflammatory cytokine involved in rheumatoid arthritis, atherosclerosis, and stroke. However, little is known about its role in breast cancer. We explored the function of IL-20 in tumor growth and metastasis, as well as in clinical outcome.
View Article and Find Full Text PDFPurpose: Interleukin (IL)-19 was expressed in invasive ductal carcinoma (IDC) of the breast tissue but not in healthy breast tissue. We explored the effects of IL-19 on the pathogenesis of breast cancer and its clinical outcome.
Experimental Design: Tumor expression of IL-19 was assessed by immunohistochemistry and/or real-time quantitative PCR between two groups of patients with breast IDC (n = 60 and 143, respectively) with available clinical and survival data.
IL-20 is a proinflammatory cytokine of the IL-10 family that is involved in psoriasis, rheumatoid arthritis, atherosclerosis, and stroke. However, little is known about the role of IL-20 in bone destruction. We explored the function of IL-20 in osteoclastogenesis and the therapeutic potential of anti-IL-20 monoclonal antibody 7E for treating osteoporosis.
View Article and Find Full Text PDFEndovascular aneurysm repair (EVAR) is an advanced minimally invasive surgical technology that is helpful for reducing patients' recovery time, postoperative morbidity and mortality. This study proposes an ensemble model to predict postoperative morbidity after EVAR. The ensemble model was developed using a training set of consecutive patients who underwent EVAR between 2000 and 2009.
View Article and Find Full Text PDFRecent studies have shown that computerized clinical case management and decision support systems can be used to assist surgeons in the diagnosis of disease, optimize surgical operation, aid in drug therapy and decrease the cost of medical treatment. Therefore, medical informatics has become an extensive field of research and many of these approaches have demonstrated potential value for improving medical quality. The aim of this study was to develop a web-based cardiovascular clinical information system (CIS) based on innovative techniques, such as electronic medical records, electronic registries and automatic feature surveillance schemes, to provide effective tools and support for clinical care, decision-making, biomedical research and training activities.
View Article and Find Full Text PDFThe crucial role of gap junctions, which are composed of connexin (Cx) protein, in auditory functions has been confirmed by numerous studies. Cx29 is a relatively new member of the Cx protein family. In this article, we report variants of the Cx29 gene in 253 unrelated Taiwanese patients with nonsyndromic hearing loss.
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